Tetracycline: Difference between revisions
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==General== | ==General== | ||
*Type: | *Type: [[Is DrugClass::Tetracyclines]] | ||
*Dosage Forms: | *Dosage Forms: | ||
*Common Trade Names: | *Common Trade Names: Sumycin | ||
==Adult Dosing== | ==Adult Dosing== | ||
*500mg PO q6-12hr | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
*>8yo: 25-50 mg/kg/day PO divided q6hr; not to exceed 3 g/day | |||
==Special Populations== | ==Special Populations== | ||
*Pregnancy: | *Pregnancy: Category D | ||
*Lactation: | *Lactation: Short term use acceptable | ||
*Renal Dosing | *Renal Dosing: reduce dose | ||
*Hepatic Dosing: contraindicated in severe impairment | |||
*Hepatic Dosing | |||
==Contraindications== | ==Contraindications== | ||
*Allergy to class/drug | *Allergy to class/drug | ||
*Severe hepatic dysfunction | |||
*Pregnancy 2nd and 3rd trimesters | |||
==Adverse Reactions== | ==Adverse Reactions== | ||
===Serious=== | ===Serious=== | ||
*Calcium Deposits in Teeth and Bones | |||
**causes tetracycline to be contraindicated in pediatrics | |||
*Nephrogenic Diabetes Insipidus | |||
*Esophageal ulceration | |||
*Hepatic toxicity, liver failure | |||
*Angioedema | |||
*Anyphilaxis | |||
*Pericarditis | |||
===Common=== | ===Common=== | ||
*Photosensitivity | |||
*[[Pseudo Tumor Cerebri]] | |||
*Myopia | |||
*Nausea/vomiting, diarrhea, esophagitis, black hairy tongue, dysphagia | |||
*Rash, onycholysis | |||
*Elevated BUN | |||
*Serum sickness-like reaction | |||
*Hemolytic anemia, thrombocytopenia, neutropenia, eosinophilia | |||
==Pharmacology== | ==Pharmacology== | ||
*Half-life: | *Half-life: 8-11hr | ||
*Metabolism: | *Metabolism: | ||
*Excretion: | *Excretion: Urine | ||
*Mechanism of Action: | *Mechanism of Action: Inhibits bacterial protein synthesis by binding with 30S and possibly 50S ribosomal subunit | ||
==See Also== | ==See Also== | ||
*[[Antibiotics (Main)]] | *[[Antibiotics (Main)]] | ||
== | ==References== | ||
<references/> | |||
[[Category:Pharmacology]] | [[Category:Pharmacology]] | ||
[[Category:ID]] | |||
Latest revision as of 16:24, 18 July 2025
General
- Type: Tetracyclines
- Dosage Forms:
- Common Trade Names: Sumycin
Adult Dosing
- 500mg PO q6-12hr
Pediatric Dosing
- >8yo: 25-50 mg/kg/day PO divided q6hr; not to exceed 3 g/day
Special Populations
- Pregnancy: Category D
- Lactation: Short term use acceptable
- Renal Dosing: reduce dose
- Hepatic Dosing: contraindicated in severe impairment
Contraindications
- Allergy to class/drug
- Severe hepatic dysfunction
- Pregnancy 2nd and 3rd trimesters
Adverse Reactions
Serious
- Calcium Deposits in Teeth and Bones
- causes tetracycline to be contraindicated in pediatrics
- Nephrogenic Diabetes Insipidus
- Esophageal ulceration
- Hepatic toxicity, liver failure
- Angioedema
- Anyphilaxis
- Pericarditis
Common
- Photosensitivity
- Pseudo Tumor Cerebri
- Myopia
- Nausea/vomiting, diarrhea, esophagitis, black hairy tongue, dysphagia
- Rash, onycholysis
- Elevated BUN
- Serum sickness-like reaction
- Hemolytic anemia, thrombocytopenia, neutropenia, eosinophilia
Pharmacology
- Half-life: 8-11hr
- Metabolism:
- Excretion: Urine
- Mechanism of Action: Inhibits bacterial protein synthesis by binding with 30S and possibly 50S ribosomal subunit