Icatibant: Difference between revisions
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*Caution if recent stroke | *Caution if recent stroke | ||
===Common=== | ===Common=== | ||
*Injection site reaction | |||
*Dizziness | |||
*Fever | |||
*Increased LFTs | |||
==Pharmacology== | ==Pharmacology== | ||
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==References== | ==References== | ||
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[[Category: | [[Category:Pharmacology]] | ||
Latest revision as of 20:37, 26 January 2019
General
- Type: Bradykinin receptor antagonist
- Dosage Forms: 30mg
- Routes of Administration: Subcutaneous
- Common Trade Names: Firazyr
Adult Dosing
Hereditary angioedema
- 30mg subcutaneous x 1
- May repeat q6h if inadequate response/symptoms recur
- Max 90mg/24 hours
Pediatric Dosing
not available (8/2015)
Special Populations
- Pregnancy Rating: C
- Lactation risk: safety unknown
- Renal Dosing
- Hepatic Dosing
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- Caution if acute MI
- Caution if unstable angina
- Caution if recent stroke
Common
- Injection site reaction
- Dizziness
- Fever
- Increased LFTs
Pharmacology
- Half-life: 1.4h
- Metabolism: Proteolytic degradation
- Excretion: Urine 10% unchanged
- Mechanism of Action: selectively antagonizes bradykinin B2 receptor
Comments
- NEJM article 1/2015 randomized 27 people with ACEi induced angioedema to icatibant vs std therapy (Prednisone 500mg + Clemastine 2mg) looking at time to resolution.
RESULTS- significantly shorter (8 hrs vs 27.1 hrs) in icatibant group.
- Cost according to Goodrx= $9,000/dose (on 8/7/2015)