Valganciclovir: Difference between revisions
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==Adult Dosing== | ==Adult Dosing== | ||
*CMV infection: 900 mg PO BID | |||
*CMV prophylaxis: 900 mg PO daily | |||
===Indications by Disease=== | ===Indications by Disease=== | ||
{{#ask: [[Has DrugName::Valganciclovir]] [[Has Population::Adult]] | {{#ask: [[Has DrugName::Valganciclovir]] [[Has Population::Adult]] | ||
|?Treats disease=Disease | |?Treats disease=Disease | ||
|?Has Dose=Dose | |?Has Dose=Dose | ||
|?Has Context=Context | |?Has Context=Context | ||
|format=table | |format=table | ||
|limit=50 | |limit=50 | ||
|mainlabel=- | |mainlabel=- | ||
|headers=show | |headers=show | ||
|sort=Treats disease | |sort=Treats disease | ||
}} | }} | ||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
*Neonatal CMV infection: 17 mg/kg PO daily BID x 12 weeks, then 17 mg/kg daily until 1 year of age | |||
===Indications by Disease=== | ===Indications by Disease=== | ||
{{#ask: [[Has DrugName::Valganciclovir]] [[Has Population::Pediatric]] | {{#ask: [[Has DrugName::Valganciclovir]] [[Has Population::Pediatric]] | ||
|?Treats disease=Disease | |?Treats disease=Disease | ||
|?Has Dose=Dose | |?Has Dose=Dose | ||
|?Has Context=Context | |?Has Context=Context | ||
|format=table | |format=table | ||
|limit=50 | |limit=50 | ||
|mainlabel=- | |mainlabel=- | ||
|headers=show | |headers=show | ||
|sort=Treats disease | |sort=Treats disease | ||
}} | }} | ||
Latest revision as of 02:38, 20 March 2026
Administration
- Type: Antiviral
- Dosage Forms:
- Routes of Administration: Oral
- Common Trade Names:
Adult Dosing
- CMV infection: 900 mg PO BID
- CMV prophylaxis: 900 mg PO daily
Indications by Disease
| Disease | Dose | Context |
|---|---|---|
| CMV retinitis | 900mg PO q12hrs x 14 days then 900mg PO q24hrs x 7 days | Severe vision threatening with intraocular implant |
| CMV retinitis | 900mg PO q12hrs x 21 days then 900mg PO q24hrs x 7 days | Peripheral lesions |
Pediatric Dosing
- Neonatal CMV infection: 17 mg/kg PO daily BID x 12 weeks, then 17 mg/kg daily until 1 year of age
Indications by Disease
Special Populations
- Pregnancy Rating: Category C, fetal risk cannot be ruled out
- Lactation risk: infant risk cannot be ruled out
- Renal dosing
- CrCl 40-59 mL/min: 450 mg BID
- CrCl 25-39 mL/min: 450 mg once daily
- CrCl 10-24 mL/min: 450 mg every 2 days
- CrCl < 10 mL/min or on HD: not recommended
- Hepatic dosing:
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- Anemia/aplastic anemia, leukopenia, thrombocytopenia, pancytopenia
Common
- Nausea/vomiting, diarrhea
- Graft rejection
- Headache
- URI
- UTI
- Fever
- Tremor
Pharmacology
- Half-life: 4-10h
- Metabolism: Hepatic
- Excretion: Renal
Mechanism of Action
- Inhibits viral DNA synthesis