Obiltoxaximab: Difference between revisions
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==Adult Dosing== | ==Adult Dosing== | ||
===Inhalation anthrax treatment=== | |||
*<40 kg | |||
**24 mg/kg IV x1 | |||
***Premed with [[diphenhydramine]] | |||
*>40 kg | |||
**16 mg/kg IV x1 | |||
***Premed with [[diphenhydramine]] | |||
===Inhalation anthrax prophylaxis, post-exposure=== | |||
*<40 kg | |||
**24 mg/kg IV x1 | |||
***Do not use as 1st line agent | |||
***Premed with [[diphenhydramine]] | |||
*>40 kg | |||
**16 mg/kg IV x1 | |||
***Do not use as 1st line agent | |||
***Premed with [[diphenhydramine]] | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
===Inhalation anthrax treatment=== | |||
*<15 kg | |||
**32 mg/kg IV x1 | |||
***Premed with [[diphenhydramine]] | |||
*16-40 kg | |||
**24 mg/kg IV x1 | |||
***Premed with [[diphenhydramine]] | |||
*>40 kg | |||
**16 mg/kg IV x1 | |||
***Premed with [[diphenhydramine]] | |||
===Inhalation anthrax prophylaxis, post-exposure=== | |||
*<15 kg | |||
**32 mg/kg IV x1 | |||
***Do not use as 1st line agent | |||
***Premed with [[diphenhydramine]] | |||
*16-40 kg | |||
**24 mg/kg IV x1 | |||
***Do not use as 1st line agent | |||
***Premed with [[diphenhydramine]] | |||
*>40 kg | |||
**16 mg/kg IV x1 | |||
***Do not use as 1st line agent | |||
***Premed with [[diphenhydramine]] | |||
==Special Populations== | ==Special Populations== | ||
| Line 98: | Line 100: | ||
[[Category:Pharmacology]] | [[Category:Pharmacology]] | ||
[[Category:ID]] | |||
Latest revision as of 00:36, 23 September 2019
Administration
- Type: Monoclonal Antibody
- Dosage Forms: IV
- Routes of Administration: IV
- Common Trade Names: Anthim
- Info: Distributed directly to CDC
Adult Dosing
Inhalation anthrax treatment
- <40 kg
- 24 mg/kg IV x1
- Premed with diphenhydramine
- 24 mg/kg IV x1
- >40 kg
- 16 mg/kg IV x1
- Premed with diphenhydramine
- 16 mg/kg IV x1
Inhalation anthrax prophylaxis, post-exposure
- <40 kg
- 24 mg/kg IV x1
- Do not use as 1st line agent
- Premed with diphenhydramine
- 24 mg/kg IV x1
- >40 kg
- 16 mg/kg IV x1
- Do not use as 1st line agent
- Premed with diphenhydramine
- 16 mg/kg IV x1
Pediatric Dosing
Inhalation anthrax treatment
- <15 kg
- 32 mg/kg IV x1
- Premed with diphenhydramine
- 32 mg/kg IV x1
- 16-40 kg
- 24 mg/kg IV x1
- Premed with diphenhydramine
- 24 mg/kg IV x1
- >40 kg
- 16 mg/kg IV x1
- Premed with diphenhydramine
- 16 mg/kg IV x1
Inhalation anthrax prophylaxis, post-exposure
- <15 kg
- 32 mg/kg IV x1
- Do not use as 1st line agent
- Premed with diphenhydramine
- 32 mg/kg IV x1
- 16-40 kg
- 24 mg/kg IV x1
- Do not use as 1st line agent
- Premed with diphenhydramine
- 24 mg/kg IV x1
- >40 kg
- 16 mg/kg IV x1
- Do not use as 1st line agent
- Premed with diphenhydramine
- 16 mg/kg IV x1
Special Populations
- Pregnancy Rating: C; Benefits outweigh risks during pregnancy.
- Lactation risk: L3; Safety unknown
Renal Dosing
- Adult: Not defined
- Pediatric: Not defined
Hepatic Dosing
- Adult: Not defined
- Pediatric: Not defined
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- Hypersensitivity reaction
- Anaphylaxis
Common
- Hypersensitivity reaction
- Headache
- URI
- Pruritus
- Cough
- Injection site reaction
- Nasal congestion
- Urticaria
- Extremity pain
Pharmacology
- Half-life: 15-23 Days
- Metabolism: Other; CYP450: unknown
- Excretion: Other
Mechanism of Action
- A monoclonal antibody that binds to anthrax toxin to prevent lethal and edema factors' intracellular entry and neutralizes toxic effects.