Colestipol: Difference between revisions

Latest revision as of 12:34, 7 January 2026

Other languages:

English
español

Administration

Type: Bile Acid Binder
Dosage Forms: 1 g tab; 5 g/scoop granules; 5 g granule packet
Routes of Administration: Oral
Common Trade Names: N/A

Adult Dosing

Digoxin toxicity, adjunct tx
- Granules: 5 g PO q6-8h
  - Start: 10 g PO x1 within 1-3h after last oral digoxin ingestion
  - Max: 30 g/day
Gallbladder surgery-associated diarrhea, adjunct tx
- Tabs: 2-16 g/day PO divided QD-QID
  - Start: 2 g PO QD-bid
  - Max: 16 g/day.
  - Do not crush/cut/chew
- Granules:5-30 g/day PO divided QD-QID
  - Start: 5 g PO QD-bid
  - Max: 30 g/day
Hypercholesterolemia
- Tabs: 2-16 g/day PO divided QD-QID
  - Start: 2 g PO QD-bid
  - Max: 16 g/day.
  - Do not crush/cut/chew
- Granules:5-30 g/day PO divided QD-QID
  - Start: 5 g PO QD-bid
  - Max: 30 g/day
Pruritus secondary to biliary obstruction
- Tabs: 2-16 g/day PO divided QD-QID
  - Start: 2 g PO QD-bid
  - Max: 16 g/day.
  - Do not crush/cut/chew
- Granules:5-30 g/day PO divided QD-QID
  - Start: 5 g PO QD-bid
  - Max: 30 g/day

Pediatric Dosing

Pediatric dosing currently unavailable.

Special Populations

Pregnancy Rating: C; Inadequate data to assess risk
Lactation risk: L3; Safety unknown

Renal Dosing

Adult: No adjustment
Pediatric: N/A

Hepatic Dosing

Adult: Not defined.
Pediatric: N/A

Contraindications

Allergy to class/drug
Caution if constipation
Caution if prolonged use

Adverse Reactions

Serious

Fecal impaction
PUD
Cholecystitis
Cholelithiasis
Esophageal obstruction

Common

Constipation
Abdominal pain
Abdominal cramps
Abdominal distention
Flatulence
Dyspepsia
Loose stool/Diarrhea
Nausea/Vomiting
ALT, AST elevation
Alk Phos. elevation
Bleeding hemorrhoids

Pharmacology

Half-life: Unknown
Metabolism: N/A
Excretion: Feces

Mechanism of Action

Binds intestinal bile acids for excretion.

Comments

References

Authors:

@@ Line 1: / Line 1: @@
-==Administration==
+<languages/>
+<translate>
+==Administration== <!--T:1-->
+<!--T:2-->
 *Type: Bile Acid Binder
 *Dosage Forms: 1 g tab; 5 g/scoop granules; 5 g granule packet
@@ Line 5: / Line 10: @@
 *Common Trade Names: N/A
-==Adult Dosing==
-*[[Digoxin toxicity]], adjunct tx
+==Adult Dosing== <!--T:3-->
+<!--T:4-->
+*[[Special:MyLanguage/Digoxin toxicity|Digoxin toxicity]], adjunct tx
 **Granules: 5 g PO q6-8h
 ***Start: 10 g PO x1 within 1-3h after last oral digoxin ingestion
 ***Max: 30 g/day
-*Gallbladder surgery-associated [[diarrhea]], adjunct tx
+*Gallbladder surgery-associated [[Special:MyLanguage/diarrhea|diarrhea]], adjunct tx
-**Tabs: 2-16 g/day PO divided qd-qid
+**Tabs: 2-16 g/day PO divided QD-QID
-***Start: 2 g PO qd-bid
+***Start: 2 g PO QD-bid
 ***Max: 16 g/day.
 ***Do not crush/cut/chew
-**Granules:5-30 g/day PO divided qd-qid
+**Granules:5-30 g/day PO divided QD-QID
-***Start: 5 g PO qd-bid
+***Start: 5 g PO QD-bid
 ***Max: 30 g/day
 *Hypercholesterolemia
-**Tabs: 2-16 g/day PO divided qd-qid
+**Tabs: 2-16 g/day PO divided QD-QID
-***Start: 2 g PO qd-bid
+***Start: 2 g PO QD-bid
 ***Max: 16 g/day.
 ***Do not crush/cut/chew
-**Granules:5-30 g/day PO divided qd-qid
+**Granules:5-30 g/day PO divided QD-QID
-***Start: 5 g PO qd-bid
+***Start: 5 g PO QD-bid
 ***Max: 30 g/day
-*[[Pruritus]] secondary to biliary obstruction
+*[[Special:MyLanguage/Pruritus|Pruritus]] secondary to biliary obstruction
-**Tabs: 2-16 g/day PO divided qd-qid
+**Tabs: 2-16 g/day PO divided QD-QID
-***Start: 2 g PO qd-bid
+***Start: 2 g PO QD-bid
 ***Max: 16 g/day.
 ***Do not crush/cut/chew
-**Granules:5-30 g/day PO divided qd-qid
+**Granules:5-30 g/day PO divided QD-QID
-***Start: 5 g PO qd-bid
+***Start: 5 g PO QD-bid
 ***Max: 30 g/day
-==Pediatric Dosing==
+==Pediatric Dosing== <!--T:5-->
+<!--T:6-->
 Pediatric dosing currently unavailable.
-==Special Populations==
-*[[Drug pregnancy categories|Pregnancy Rating]]: C; Inadequate data to assess risk
+==Special Populations== <!--T:7-->
+<!--T:8-->
+*[[Special:MyLanguage/Drug pregnancy categories|Pregnancy Rating]]: C; Inadequate data to assess risk
 *Lactation risk: L3; Safety unknown
-===Renal Dosing===
+===Renal Dosing=== <!--T:9-->
+<!--T:10-->
 *Adult: No adjustment
 *Pediatric: N/A
-===Hepatic Dosing===
+===Hepatic Dosing=== <!--T:11-->
+<!--T:12-->
 *Adult: Not defined.
 *Pediatric: N/A
-==Contraindications==
+==Contraindications== <!--T:13-->
+<!--T:14-->
 *Allergy to class/drug
 *Caution if constipation
 *Caution if prolonged use
-==Adverse Reactions==
-===Serious===
+==Adverse Reactions== <!--T:15-->
+===Serious=== <!--T:16-->
+<!--T:17-->
 *Fecal impaction
-*[[PUD]]
+*[[Special:MyLanguage/PUD|PUD]]
-*[[Cholecystitis]]
+*[[Special:MyLanguage/Cholecystitis|Cholecystitis]]
-*[[Cholelithiasis]]
+*[[Special:MyLanguage/Cholelithiasis|Cholelithiasis]]
 *Esophageal obstruction
-===Common===
-*[[Constipation]]
+===Common=== <!--T:18-->
+<!--T:19-->
+*[[Special:MyLanguage/Constipation|Constipation]]
 *Abdominal pain
 *Abdominal cramps
 *Abdominal distention
 *Flatulence
-*[[Dyspepsia]]
+*[[Special:MyLanguage/Dyspepsia|Dyspepsia]]
-*Loose stool/[[Diarrhea]]
+*Loose stool/[[Special:MyLanguage/Diarrhea|Diarrhea]]
-*[[Nausea]]/[[Vomiting]]
+*[[Special:MyLanguage/Nausea|Nausea]]/[[Special:MyLanguage/Vomiting|Vomiting]]
 *ALT, AST elevation
 *Alk Phos. elevation
-*Bleeding [[hemorrhoids]]
+*Bleeding [[Special:MyLanguage/hemorrhoids|hemorrhoids]]
+==Pharmacology== <!--T:20-->
-==Pharmacology==
+<!--T:21-->
 *Half-life: Unknown
 *Metabolism: N/A
 *Excretion: Feces
-==Mechanism of Action==
+==Mechanism of Action== <!--T:22-->
+<!--T:23-->
 Binds intestinal bile acids for excretion.
-==Comments==
+==Comments== <!--T:24-->
+==See Also== <!--T:25-->
+<!--T:26-->
+[[Special:MyLanguage/Digoxin toxicity|Digoxin toxicity]]
-==See Also==
+==References== <!--T:27-->
-[[Digoxin toxicity]]
-==References==
+<!--T:28-->
 <references/>
+<!--T:29-->
 [[Category:Pharmacology]]
+[[Category:GI]]
+[[Category:Toxicology]]
+</translate>