Insulin: Difference between revisions

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{| width="342" border="1"
==Types==
| Type
{| class="wikitable"  
| Onset of action (h)
| Peak action
| Effective duration
| Max duration
|-
|-
| colspan="5" | RAPID ACTING
| <u>'''Type'''</u>
| <u>'''Onset of action (h)'''</u>
| <u>'''Peak action'''</u>
| <u>'''Effective duration'''</u>
| <u>'''Max duration'''</u>
|-
|-
|
| colspan="5" | '''RAPID ACTING'''
|-
|  
Lispro
Lispro


(humalog)
(humalog)
| 0.25-0.5 <br />
 
| 0.25-0.5<br/>
| 0.5-1.25
| 0.5-1.25
| 3-4
| 3-4
| 4-6
| 4-6
|-
|-
|
|  
Aspart
Aspart


(novolog)
(novolog)
| 0.25-0.5<br />
 
| 0.25-0.5<br/>
| 0.5-1.25
| 0.5-1.25
| 3-4
| 3-4
| 4-6
| 4-6
|-
|-
|
|  
Glulisine
Glulisine


(apidra)
(apidra)
| 0.25-0.5
| 0.25-0.5
| 0.25-1.25 <br />
| 0.25-1.25<br/>
| 3-4
| 3-4
| 4-6
| 4-6
|-
|-
| colspan="5" | SHORT ACTING<br />
| colspan="5" | '''SHORT ACTING<br/>'''
|-
|-
| Regular
| Regular
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| 6-8
| 6-8
|-
|-
| colspan="5" | INTERMEDIATE ACTING
| colspan="5" | '''INTERMEDIATE ACTING'''
|-
|-
| NPH
| NPH
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| 14-18
| 14-18
|-
|-
| colspan="5" | LONG ACTING
| colspan="5" | '''LONG ACTING'''
|-
|-
|
|  
glargine
glargine


(Lantus)
(Lantus)
| 3-4
| 3-4
| 8-16
| 8-16
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| 20-24
| 20-24
|-
|-
|
|  
detemir
detemir


(Levemir)
(Levemir)
| 3-4
| 3-4
| 6-8
| 6-8
| 14
| 14
| ~20
| ~20
|}  
|}


[[File:Insulin.jpg|thumbnail]]


Type Onset of action (h) Peak action Effective duration Max duration
{{Common Anti-hyperglycemic Drugs and Pharmacology}}
RAPID ACTING
Lispro


(humalog)  
==Insulin Sliding Scale==
*Dosing depends on the patient's level of insulin resistance.
*The example sliding scales are for regular insulin with blood glucose (BG) measured in mg/dL


0.25-0.5 0.5-1.25 3-4 4-6
===Low Dose (Renal Insufficiency)===
Aspart
*BG 150-199: 1 unit bolus Insulin
*BG 200-249: 2 units bolus Insulin
*BG 250-299: 3 units bolus Insulin
*BG 300-349: 4 units bolus Insulin
*BG Over 350: 5 units bolus Insulin


(novolog)  
===Medium Dose (Standard)===
*BG 150-199: 1 unit bolus Insulin
*BG 200-249: 3 units bolus Insulin
*BG 250-299: 5 units bolus Insulin
*BG 300-349: 7 units bolus Insulin
*BG Over 350: 8 units bolus Insulin


0.25-0.5 0.5-1.25 3-4 4-6
===High Dose (Severely Insulin Resistant)===
Glulisine
*BG 150-199: 2 unit bolus Insulin
*BG 200-249: 4 units bolus Insulin
*BG 250-299: 7 units bolus Insulin
*BG 300-349: 10 units bolus Insulin
*BG Over 350: 12 units bolus Insulin


(apidra)
0.25-0.5 0.25-1.25  3-4 4-6
SHORT ACTING
Regular 0.5-1 2-3 3-6 6-8
INTERMEDIATE ACTING
NPH 2-4 6-10 10-16 14-18
LONG ACTING
glargine
(Lantus)
3-4 8-16 18-20 20-24
detemir
(Levemir)


3-4 6-8 14 ~20
==Indications by Condition==
''The following table is automatically generated from disease/condition pages across WikEM.''


{{#ask:[[Has DrugName::Insulin]]
|?Has Indication=Indication
|?Has Dose=Dose
|?Has Context=Context
|?Has Route=Route
|?Has Population=Population
|format=table
|headers=plain
|mainlabel=-
|sort=Has Indication
|limit=50
}}


==See Also==
*[[Diabetes (Main)]]


==References==
<references/>


[[Category:Drugs]]
[[Category:Pharmacology]]
[[Category:Endocrinology]]

Latest revision as of 09:11, 22 March 2026

Types

Type Onset of action (h) Peak action Effective duration Max duration
RAPID ACTING

Lispro

(humalog)

0.25-0.5
 0.5-1.25 3-4 4-6

Aspart

(novolog)

0.25-0.5
 0.5-1.25 3-4 4-6

Glulisine

(apidra)

0.25-0.5 0.25-1.25
 3-4 4-6
SHORT ACTING
Regular 0.5-1 2-3 3-6 6-8
INTERMEDIATE ACTING
NPH 2-4 6-10 10-16 14-18
LONG ACTING

glargine

(Lantus)

3-4 8-16 18-20 20-24

detemir

(Levemir)

3-4 6-8 14 ~20
Insulin.jpg

Common Anti-hyperglycemic Drugs and Pharmacology

Drug Pharmacology
Onset Peak Duration
Rapid-acting insulin

  • Aspart (Novolog)
  • Lispro (Humalog)
 15-30min 1-2h 3-5h
Short-acting insulin

  • Regular
 30-60min 2-4h 6-10h
Intermediate-acting insulin

  • NPH (Humulin, Novolin)
 1-3h 4-12h 18-24h
Long-acting insulin

  • Glargine (Lantus)
 2-4h None 24h
Sulfonylurea

  • Glimepiride
  • Glipizide (Glucotrol)
  • Glyburide (Glycron, Micronase)
 – 2-6h 12-24h

See also GLP-1 agonists

Insulin Sliding Scale

  • Dosing depends on the patient's level of insulin resistance.
  • The example sliding scales are for regular insulin with blood glucose (BG) measured in mg/dL

Low Dose (Renal Insufficiency)

  • BG 150-199: 1 unit bolus Insulin
  • BG 200-249: 2 units bolus Insulin
  • BG 250-299: 3 units bolus Insulin
  • BG 300-349: 4 units bolus Insulin
  • BG Over 350: 5 units bolus Insulin

Medium Dose (Standard)

  • BG 150-199: 1 unit bolus Insulin
  • BG 200-249: 3 units bolus Insulin
  • BG 250-299: 5 units bolus Insulin
  • BG 300-349: 7 units bolus Insulin
  • BG Over 350: 8 units bolus Insulin

High Dose (Severely Insulin Resistant)

  • BG 150-199: 2 unit bolus Insulin
  • BG 200-249: 4 units bolus Insulin
  • BG 250-299: 7 units bolus Insulin
  • BG 300-349: 10 units bolus Insulin
  • BG Over 350: 12 units bolus Insulin


Indications by Condition

The following table is automatically generated from disease/condition pages across WikEM.

IndicationDoseContextRoutePopulation
Beta-blocker toxicity1 unit/kg IV bolus with D50, then 0.5-1 unit/kg/hr dripHigh-dose insulin euglycemic therapyIV/IV dripAdult
Calcium channel blocker toxicity1 unit/kg IV bolus with D50, then 0.5-1 unit/kg/hr drip (max 2 units/kg/hr)High-dose insulin euglycemic therapy (best evidence)IV/IV dripAdult
Diabetic ketoacidosis0.1 units/kg/hr IV infusion (no bolus); reduce to 0.02-0.05 units/kg/hr when BG <250IV insulin for moderate-severe DKAIV dripAdult
Diabetic ketoacidosis0.3 units/kg SC initial, then 0.1-0.2 units/kg SC q1-2hSC insulin for mild DKA onlySCAdult
Diabetic ketoacidosis (peds)0.1 units/kg/hr IV dripDKA managementIV dripPediatric

See Also

References

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