Neomycin: Difference between revisions
Neil.m.young (talk | contribs) (Text replacement - "5 mg" to "5mg") |
Neil.m.young (talk | contribs) (Text replacement - "0 mg" to "0mg") |
||
| Line 7: | Line 7: | ||
==Adult Dosing== | ==Adult Dosing== | ||
Bowel Prep | Bowel Prep | ||
* | *1000mg PO at 1 pm, 2 pm and 11 pm the day before 8 am surgery. Alternative: 1000mg po q1h x 4, then 1000mg po q4h x 4 | ||
Hepatic Encephalopathy | Hepatic Encephalopathy | ||
*1000- | *1000-3000mg po q6h x 5-6 days | ||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
Bowel prep for 2-12 y/o | Bowel prep for 2-12 y/o | ||
*25mg/kg PO at 1 pm, 2 pm and 11 pm the day before 8 am surgery. Alternative: | *25mg/kg PO at 1 pm, 2 pm and 11 pm the day before 8 am surgery. Alternative: 90mg/kg/day PO divided q4h x 2-3 days | ||
==Special Populations== | ==Special Populations== | ||
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]:D | *[[Drug Ratings in Pregnancy|Pregnancy Rating]]:D | ||
Revision as of 05:53, 20 July 2016
Administration
- Type: Aminoglycoside; bowel preps
- Dosage Forms: 500
- Routes of Administration: PO
- Common Trade Names: Neo-Fradin
Adult Dosing
Bowel Prep
- 1000mg PO at 1 pm, 2 pm and 11 pm the day before 8 am surgery. Alternative: 1000mg po q1h x 4, then 1000mg po q4h x 4
Hepatic Encephalopathy
- 1000-3000mg po q6h x 5-6 days
Pediatric Dosing
Bowel prep for 2-12 y/o
- 25mg/kg PO at 1 pm, 2 pm and 11 pm the day before 8 am surgery. Alternative: 90mg/kg/day PO divided q4h x 2-3 days
Special Populations
- Pregnancy Rating:D
- Lactation risk: safety unknown
Renal Dosing
- Adult: not defined
- Pediatric:not defined
Hepatic Dosing
- Adult:not defined
- Pediatric:not defined
Contraindications
- Allergy to class/drug
- GI obstruction
Adverse Reactions
Serious
- nephrotoxicity
- ototoxicity
- neurotoxicity
- superinfection
Common
- nausea
- vomiting
- diarrhea
Pharmacology
- Half-life: 2-3 hour
- Metabolism: none
- Excretion: feces
Mechanism of Action
Bactericidal and amebicidal; binds to bacterial 30s ribosomal subunit, inhibiting protein synthesis, suppresses urease producing bacteria; reducing ammonia absorption from gut