Tramadol: Difference between revisions
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==Adult Dosing== | ==Adult Dosing== | ||
===General=== | ===General=== | ||
Pain: | *Pain: | ||
*50-100 mg PO q4-6h PRN | **50-100 mg PO q4-6h PRN | ||
*Chronic severe pain: | |||
*100-300 mg ER PO QDAY | **100-300 mg ER PO QDAY | ||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
Not Currently recommended | *Not Currently recommended | ||
==Special Populations== | ==Special Populations== | ||
Revision as of 15:08, 11 July 2016
General
- Type: opioid
- Dosage Forms: PO
- Common Trade Names: Ultram, Ryzolt
Adult Dosing
General
- Pain:
- 50-100 mg PO q4-6h PRN
- Chronic severe pain:
- 100-300 mg ER PO QDAY
Pediatric Dosing
- Not Currently recommended
Special Populations
- Pregnancy Rating: C
- Lactation Risk Categories: Probably safe
- Renal Dosing
- Adult: CrCL < 30: given q12h, max 200 mg/day
- Pediatric: none
- Hepatic Dosing
- Adult: cirrhosis: 50 mg q12h, max 100 mg/day
- Pediatric: not defined
Contraindications
- Allergy to class/drug
- asthma, acute
- respiratory depression
- severe hepatic impairment
- severe renal impairment
- acute alcohol intoxication
Adverse Reactions
Serious
- Respiratory Depression
- suicidal ideation
- Seizures
- anaphylaxis
- serotonin syndrome
- steven johnson syndrome
Common
- Nausea
- Rash
- Headache
- Fatigue
- xerostomia
- constipation
- Tremor
- insomnia
Pharmacology
- Half-life: 6.3 - 7.9 hour
- Metabolism: Liver
- Excretion: urine
- Mechanism of Action:exact mechanism unknown, binds to mu opioid receptors and weakly inhibits NE/Serotonin reuptake