Hydrochlorothiazide: Difference between revisions
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*HTN: 12.5 - 50 MG PO QDAY | *HTN: 12.5 - 50 MG PO QDAY | ||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
* < 6 months: 2-4 mg/kg/day PO BID | *< 6 months: 2-4 mg/kg/day PO BID | ||
* 6 mo - 2 yo: 1-2 mg/kg/day PO BID, max 37.5 mg/day | *6 mo - 2 yo: 1-2 mg/kg/day PO BID, max 37.5 mg/day | ||
* 2 - 12 y/o: 1-2 mg/kg/day PO qday-bid, max 100 mg/day | *2 - 12 y/o: 1-2 mg/kg/day PO qday-bid, max 100 mg/day | ||
==Special Populations== | ==Special Populations== | ||
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]:B | *[[Drug Ratings in Pregnancy|Pregnancy Rating]]:B | ||
| Line 24: | Line 24: | ||
==Contraindications== | ==Contraindications== | ||
*Allergy to class/drug | *Allergy to class/drug | ||
* Anuria | *Anuria | ||
* neonatal jaundice | *neonatal jaundice | ||
==Adverse Reactions== | ==Adverse Reactions== | ||
===Serious=== | ===Serious=== | ||
* hypokalemia, severe | *hypokalemia, severe | ||
* arrythmias | *arrythmias | ||
* cholestatic jaundice | *cholestatic jaundice | ||
* pancreatitis | *pancreatitis | ||
*steven johnson syndrome | *steven johnson syndrome | ||
* renal failure | *renal failure | ||
*leukopenia | *leukopenia | ||
===Common=== | ===Common=== | ||
*hypokalemia | *hypokalemia | ||
* hypochloremia | *hypochloremia | ||
*hyponatremia | *hyponatremia | ||
*hypomagnesium | *hypomagnesium | ||
Revision as of 11:37, 10 July 2016
General
- Type: diuretic
- Dosage Forms: 12.5, 25, 50
- Common Trade Names: Microzide, Esidrix
- Must check chem 10 before prescribing in ED
Adult Dosing
- HTN: 12.5 - 50 MG PO QDAY
Pediatric Dosing
- < 6 months: 2-4 mg/kg/day PO BID
- 6 mo - 2 yo: 1-2 mg/kg/day PO BID, max 37.5 mg/day
- 2 - 12 y/o: 1-2 mg/kg/day PO qday-bid, max 100 mg/day
Special Populations
- Pregnancy Rating:B
- Lactation: probably safe
- Renal Dosing
- Adult: caution advised
- Pediatric: caution advised
- Hepatic Dosing
- Adult: not defined
- Pediatric: not defined
Contraindications
- Allergy to class/drug
- Anuria
- neonatal jaundice
Adverse Reactions
Serious
*hypokalemia, severe
- arrythmias
- cholestatic jaundice
- pancreatitis
- steven johnson syndrome
- renal failure
- leukopenia
Common
- hypokalemia
- hypochloremia
- hyponatremia
- hypomagnesium
- hypercalcemia
- hyperglycemia
- hyperlipidemia
- dizziness
- diarrhea
- headache
- muscle cramps
Pharmacology
- Half-life: 5.6 - 14.8 hours
- Metabolism: none
- Excretion: urine
- Mechanism of Action: ihibits distal convoluted tubule sodium and chloride resorption