Tramadol: Difference between revisions
Ostermayer (talk | contribs) (Text replacement - "Category:Drugs" to "Category:Pharmacology") |
Neil.m.young (talk | contribs) (Text replacement - "* " to "*") |
||
| Line 28: | Line 28: | ||
*Allergy to class/drug | *Allergy to class/drug | ||
*asthma, acute | *asthma, acute | ||
* respiratory depression | *respiratory depression | ||
* severe hepatic impairment | *severe hepatic impairment | ||
* severe renal impairment | *severe renal impairment | ||
* acute alcohol intoxication | *acute alcohol intoxication | ||
==Adverse Reactions== | ==Adverse Reactions== | ||
===Serious=== | ===Serious=== | ||
*Respiratory Depression | *Respiratory Depression | ||
* suicidal ideation | *suicidal ideation | ||
*Seizures | *Seizures | ||
*anaphylaxis | *anaphylaxis | ||
*serotonin syndrome | *serotonin syndrome | ||
* steven johnson syndrome | *steven johnson syndrome | ||
===Common=== | ===Common=== | ||
| Line 50: | Line 50: | ||
*constipation | *constipation | ||
*Tremor | *Tremor | ||
* insomnia | *insomnia | ||
==Pharmacology== | ==Pharmacology== | ||
Revision as of 16:51, 9 July 2016
General
- Type: opioid
- Dosage Forms: PO
- Common Trade Names: Ultram, Ryzolt
Adult Dosing
General
Pain:
- 50-100 mg PO q4-6h PRN,
Chronic severe pain:
- 100-300 mg ER PO QDAY
Pediatric Dosing
Not Currently recommended
Special Populations
- Pregnancy Rating: C
- Lactation Risk Categories: Probably safe
- Renal Dosing
- Adult: CrCL < 30: given q12h, max 200 mg/day
- Pediatric: none
- Hepatic Dosing
- Adult: cirrhosis: 50 mg q12h, max 100 mg/day
- Pediatric: not defined
Contraindications
- Allergy to class/drug
- asthma, acute
- respiratory depression
- severe hepatic impairment
- severe renal impairment
- acute alcohol intoxication
Adverse Reactions
Serious
- Respiratory Depression
- suicidal ideation
- Seizures
- anaphylaxis
- serotonin syndrome
- steven johnson syndrome
Common
- Nausea
- Rash
- Headache
- Fatigue
- xerostomia
- constipation
- Tremor
- insomnia
Pharmacology
- Half-life: 6.3 - 7.9 hour
- Metabolism: Liver
- Excretion: urine
- Mechanism of Action:exact mechanism unknown, binds to mu opioid receptors and weakly inhibits NE/Serotonin reuptake