Cyproheptadine: Difference between revisions
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==Adult Dosing== | ==Adult Dosing== | ||
* initial dose of 12 mg is recommended, followed by 2 mg every two hours until clinical response is seen | *initial dose of 12 mg is recommended, followed by 2 mg every two hours until clinical response is seen | ||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
*Children younger than two years can be given approximately 0.06 mg/kg per dose every six hours, if needed (not to exceed 0.25 mg/kg/day). | *Children younger than two years can be given approximately 0.06 mg/kg per dose every six hours, if needed (not to exceed 0.25 mg/kg/day). | ||
| Line 18: | Line 18: | ||
===Renal Dosing=== | ===Renal Dosing=== | ||
* No recommendations | *No recommendations | ||
===Hepatic Dosing=== | ===Hepatic Dosing=== | ||
* No recommendations | *No recommendations | ||
==Contraindications== | ==Contraindications== | ||
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==Mechanism of Action== | ==Mechanism of Action== | ||
* Histamine-1 receptor antagonist | *Histamine-1 receptor antagonist | ||
*5-HT1A and 5-HT2A (seritonin) antagonistic properties | *5-HT1A and 5-HT2A (seritonin) antagonistic properties | ||
*Weak anticholinergic activity | *Weak anticholinergic activity | ||
Revision as of 14:11, 5 July 2016
Uses
- Treatment of serotonin syndrome
Administration
- Dosage Forms: 4 mg tab, 2 mg/5ml solution
- Routes of Administration: oral
- Common Trade Names: Periactin or Peritol
Adult Dosing
- initial dose of 12 mg is recommended, followed by 2 mg every two hours until clinical response is seen
Pediatric Dosing
- Children younger than two years can be given approximately 0.06 mg/kg per dose every six hours, if needed (not to exceed 0.25 mg/kg/day).
- Children two to six years can be given 2 mg every six hours, if needed (not to exceed 12 mg/day).
- Children 7 to 14 years can be given 4 mg every six hours, if needed (not to exceed 16 mg/day).
Special Populations
Renal Dosing
- No recommendations
Hepatic Dosing
- No recommendations
Contraindications
- Allergy to class/drug
- Treatment in newborns or nursing mothers
Adverse Reactions
Serious
- Hypotension
Common
- Sedation
Mechanism of Action
- Histamine-1 receptor antagonist
- 5-HT1A and 5-HT2A (seritonin) antagonistic properties
- Weak anticholinergic activity
Comments
See Also
References
- 1. Boyer EW. Serotonin syndrome. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. (Accessed on January 11, 2016.)