Insulin: Difference between revisions

Latest revision as of 07:47, 9 June 2016

Types

Type	Onset of action (h)	Peak action	Effective duration	Max duration
RAPID ACTING
Lispro (humalog)	0.25-0.5	0.5-1.25	3-4	4-6
Aspart (novolog)	0.25-0.5	0.5-1.25	3-4	4-6
Glulisine (apidra)	0.25-0.5	0.25-1.25	3-4	4-6
SHORT ACTING
Regular	0.5-1	2-3	3-6	6-8
INTERMEDIATE ACTING
NPH	2-4	6-10	10-16	14-18
LONG ACTING
glargine (Lantus)	3-4	8-16	18-20	20-24
detemir (Levemir)	3-4	6-8	14	~20

Common Anti-hyperglycemic Drugs and Pharmacology

Drug	Pharmacology
Drug	Onset	Peak	Duration
Rapid-acting insulin Aspart (Novolog) Lispro (Humalog)	15-30min	1-2h	3-5h
Short-acting insulin Regular	30-60min	2-4h	6-10h
Intermediate-acting insulin NPH (Humulin, Novolin)	1-3h	4-12h	18-24h
Long-acting insulin Glargine (Lantus)	2-4h	None	24h
Sulfonylurea Glimepiride Glipizide (Glucotrol) Glyburide (Glycron, Micronase)	–	2-6h	12-24h

Insulin Sliding Scale

Dosing depends on the patient's level of insulin resistance.
The example sliding scales are for regular insulin with blood glucose (BG) measured in mg/dL

Low Dose (Renal Insufficiency)

BG 150-199: 1 unit bolus Insulin
BG 200-249: 2 units bolus Insulin
BG 250-299: 3 units bolus Insulin
BG 300-349: 4 units bolus Insulin
BG Over 350: 5 units bolus Insulin

Medium Dose (Standard)

BG 150-199: 1 unit bolus Insulin
BG 200-249: 3 units bolus Insulin
BG 250-299: 5 units bolus Insulin
BG 300-349: 7 units bolus Insulin
BG Over 350: 8 units bolus Insulin

High Dose (Severely Insulin Resistant)

BG 150-199: 2 unit bolus Insulin
BG 200-249: 4 units bolus Insulin
BG 250-299: 7 units bolus Insulin
BG 300-349: 10 units bolus Insulin
BG Over 350: 12 units bolus Insulin

@@ Line 1: / Line 1: @@
+==Types==
+{| class="wikitable"
-Type	Onset of action (h)	Peak action 	Effective duration	Max duration
+|-
-RAPID ACTING
+| <u>'''Type'''</u>
+| <u>'''Onset of action (h)'''</u>
+| <u>'''Peak action'''</u>
+| <u>'''Effective duration'''</u>
+| <u>'''Max duration'''</u>
+|-
+| colspan="5" | '''RAPID ACTING'''
+|-
+|
 Lispro
 (humalog)
-.25-0.5 	0.5-1.25	3-4 	4-6
+| 0.25-0.5<br/>
+| 0.5-1.25
+| 3-4
+| 4-6
+|-
+|
 Aspart
 (novolog)
-.25-0.5 	0.5-1.25	3-4 	4-6
+| 0.25-0.5<br/>
+| 0.5-1.25
+| 3-4
+| 4-6
+|-
+|
 Glulisine
 (apidra)
-.25-0.5	0.25-1.25  	3-4 	4-6
+| 0.25-0.5
-SHORT ACTING
+| 0.25-1.25<br/>
-Regular 	0.5-1 	2-3 	3-6 	6-8
+| 3-4
-INTERMEDIATE ACTING
+| 4-6
-NPH	2-4	6-10	10-16	14-18
+|-
-LONG ACTING
+| colspan="5" | '''SHORT ACTING<br/>'''
+|-
+| Regular
+| 0.5-1
+| 2-3
+| 3-6
+| 6-8
+|-
+| colspan="5" | '''INTERMEDIATE ACTING'''
+|-
+| NPH
+| 2-4
+| 6-10
+| 10-16
+| 14-18
+|-
+| colspan="5" | '''LONG ACTING'''
+|-
+|
 glargine
 (Lantus)
--4	8-16	18-20	20-24
+| 3-4
+| 8-16
+| 18-20
+| 20-24
+|-
+|
 detemir
 (Levemir)
--4	6-8	14	~20
+| 3-4
+| 6-8
+| 14
+| ~20
+|}
+[[File:Insulin.jpg|thumbnail]]
+{{Common Anti-hyperglycemic Drugs and Pharmacology}}
+==Insulin Sliding Scale==
+*Dosing depends on the patient's level of insulin resistance.
+*The example sliding scales are for regular insulin with blood glucose (BG) measured in mg/dL
+===Low Dose (Renal Insufficiency)===
+*BG 150-199: 1 unit bolus Insulin
+*BG 200-249: 2 units bolus Insulin
+*BG 250-299: 3 units bolus Insulin
+*BG 300-349: 4 units bolus Insulin
+*BG Over 350: 5 units bolus Insulin
+===Medium Dose (Standard)===
+*BG 150-199: 1 unit bolus Insulin
+*BG 200-249: 3 units bolus Insulin
+*BG 250-299: 5 units bolus Insulin
+*BG 300-349: 7 units bolus Insulin
+*BG Over 350: 8 units bolus Insulin
+===High Dose (Severely Insulin Resistant)===
+*BG 150-199: 2 unit bolus Insulin
+*BG 200-249: 4 units bolus Insulin
+*BG 250-299: 7 units bolus Insulin
+*BG 300-349: 10 units bolus Insulin
+*BG Over 350: 12 units bolus Insulin
+==See Also==
+*[[Diabetes (Main)]]
-[[Category:Drugs]]
+[[Category:Pharmacology]]
+[[Category:Endocrinology]]