Template:Factor Xa Inhibitor Reversal: Difference between revisions
(Created page with "===Factor Xa Inhibitor Reversal=== {| {{table}} | align="center" style="background:#f0f0f0;"|'''Anticoagulant''' | align="center" style="background:#f0f0f0;"|'''Half-life''' |...") |
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| [[Edoxaban]] (Savaysa®)||10-14 hrs (longer in renal impairment)||~ 25%||As above | | [[Edoxaban]] (Savaysa®)||10-14 hrs (longer in renal impairment)||~ 25%||As above | ||
|- | |- | ||
| [[Rivaroxaban]] (Xarelto®)||9-13 hrs (longer in renal impairment)||No||As above | | [[Rivaroxaban reversal|Rivaroxaban]] (Xarelto®)||9-13 hrs (longer in renal impairment)||No||As above | ||
|- | |- | ||
| [[Fondaparinux]] (Arixtra®)||17-21 hrs (significantly longer in renal impairment)||No||4-factor [[PCC]] (Kcentra™)^ 50 units/kg—max 5000 units | | [[Fondaparinux]] (Arixtra®)||17-21 hrs (significantly longer in renal impairment)||No||4-factor [[PCC]] (Kcentra™)^ 50 units/kg—max 5000 units | ||
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^Off-label | ^Off-label | ||
Revision as of 13:13, 28 April 2016
Factor Xa Inhibitor Reversal
| Anticoagulant | Half-life | Removed by HD | Strategies to reverse or minimize anticoagulant effects |
| Apixaban (Eliquis®) | 8-15 hrs (longer in renal impairment) | No |
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| Edoxaban (Savaysa®) | 10-14 hrs (longer in renal impairment) | ~ 25% | As above |
| Rivaroxaban (Xarelto®) | 9-13 hrs (longer in renal impairment) | No | As above |
| Fondaparinux (Arixtra®) | 17-21 hrs (significantly longer in renal impairment) | No | 4-factor PCC (Kcentra™)^ 50 units/kg—max 5000 units |
^Off-label