Neomycin: Difference between revisions
(Created page with "==Administration== *Type: Aminoglycoside; bowel preps *Dosage Forms: 500 *Routes of Administration: PO *Common Trade Names: Neo-Fradin ==Adult Dosing== Bowel Prep * 1000 mg P...") |
Ostermayer (talk | contribs) (Text replacement - "Category:Drugs" to "Category:Pharmacology") |
||
| Line 50: | Line 50: | ||
==References== | ==References== | ||
<references/> | <references/> | ||
[[Category: | [[Category:Pharmacology]] | ||
Revision as of 15:54, 22 March 2016
Administration
- Type: Aminoglycoside; bowel preps
- Dosage Forms: 500
- Routes of Administration: PO
- Common Trade Names: Neo-Fradin
Adult Dosing
Bowel Prep
- 1000 mg PO at 1 pm, 2 pm and 11 pm the day before 8 am surgery. Alternative: 1000 mg po q1h x 4, then 1000 mg po q4h x 4
Hepatic Encephalopathy
- 1000-3000 mg po q6h x 5-6 days
Pediatric Dosing
Bowel prep for 2-12 y/o
- 25 mg/kg PO at 1 pm, 2 pm and 11 pm the day before 8 am surgery. Alternative: 90 mg/kg/day PO divided q4h x 2-3 days
Special Populations
- Pregnancy Rating:D
- Lactation risk: safety unknown
Renal Dosing
- Adult: not defined
- Pediatric:not defined
Hepatic Dosing
- Adult:not defined
- Pediatric:not defined
Contraindications
- Allergy to class/drug
- GI obstruction
Adverse Reactions
Serious
- nephrotoxicity
- ototoxicity
- neurotoxicity
- superinfection
Common
- nausea
- vomiting
- diarrhea
Pharmacology
- Half-life: 2-3 hour
- Metabolism: none
- Excretion: feces
Mechanism of Action
Bactericidal and amebicidal; binds to bacterial 30s ribosomal subunit, inhibiting protein synthesis, suppresses urease producing bacteria; reducing ammonia absorption from gut