Azathioprine: Difference between revisions
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*[[Lactation risk categories|Lactation risk]]: | *[[Lactation risk categories|Lactation risk]]: | ||
===Renal Dosing=== | ===Renal Dosing=== | ||
*Adult: | *Adult: CrCl 10-50: decr. dose 25%; CrCl <10: decr. dose 50%; HD: give 0.25 mg/kg supplement; PD: not defined | ||
*Pediatric: | *Pediatric: | ||
===Hepatic Dosing=== | ===Hepatic Dosing=== | ||
*Adult: | *Adult: | ||
Revision as of 02:38, 9 February 2016
Administration
- Type: immunosuppressant
- Dosage Forms: 50
- Routes of Administration: PO (IV form unavailable in US)
- Common Trade Names: Azasan, Imuran
Adult Dosing
Kidney transplant rejection prophylaxis
- 1-3 mg/kg PO qd
- Start: 3-5 mg/kg PO x1 up to 3 days before transplant; Info: transplant protocols may vary
Rheumatoid arthritis, severe
- 1-2.5 mg/kg/day PO divided qd-bid
- Start: 1 mg/kg/day PO divided qd-bid; Max: 2.5 mg/kg/day; Info: after 6-8wk may incr. 0.5 mg/kg/day q4wk
Crohns Disease
- 100-250 mg PO qd
- Start: 50 mg PO qd; Max: 2.5 mg/kg/day; Info: for induction or remission maintenance and fistulizing disease, steroid-sparing effects
Ulcerative colitis
- 100-250 mg PO qd
- Start: 50 mg PO qd; Max: 2.5 mg/kg/day; Info: for induction or remission maintenance, steroid-sparing effects
Pediatric Dosing
Special Populations
Renal Dosing
- Adult: CrCl 10-50: decr. dose 25%; CrCl <10: decr. dose 50%; HD: give 0.25 mg/kg supplement; PD: not defined
- Pediatric:
Hepatic Dosing
- Adult:
- Pediatric:
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
Common
Pharmacology
- Half-life:
- Metabolism:
- Excretion: