Paromomycin: Difference between revisions
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==Adult Dosing== | ==Adult Dosing== | ||
===Intestinal [[amebiasis]]=== | |||
*25-35 mg/kg/day PO divided tid x5-10 days | |||
**Give w/ food | **Give w/ food | ||
===[[Hepatic encephalopathy]]=== | |||
*adjunct tx: 1000 mg PO qid x5-6 days | |||
**Give w/ food | **Give w/ food | ||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
===Intestinal [[amebiasis]]=== | |||
*25-35 mg/kg/day PO divided tid x5-10 days | |||
==Special Populations== | ==Special Populations== | ||
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*enterocolitis | *enterocolitis | ||
===Common=== | ===Common=== | ||
*nausea | *[[nausea]] | ||
*abdominal cramps | *abdominal cramps | ||
*diarrhea | *[[diarrhea]] | ||
==Pharmacology== | ==Pharmacology== | ||
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==References== | ==References== | ||
<references/> | <references/> | ||
UpToDate, Epocrates | |||
[[Category:Drugs]] | |||
Revision as of 12:17, 7 February 2016
Administration
- Type: Amebicide
- Dosage Forms: 250
- Routes of Administration: Oral
- Common Trade Names: Humatin
Adult Dosing
Intestinal amebiasis
- 25-35 mg/kg/day PO divided tid x5-10 days
- Give w/ food
Hepatic encephalopathy
- adjunct tx: 1000 mg PO qid x5-6 days
- Give w/ food
Pediatric Dosing
Intestinal amebiasis
- 25-35 mg/kg/day PO divided tid x5-10 days
Special Populations
- Poorly absorbed when given orally
- Use during pregnancy has limited data
Renal Dosing
- No change in dosing
Hepatic Dosing
- No change in dosing
Contraindications
- Allergy to class/drug
- GI obstruction
- caution if ulcerative colitis
- caution if inflammatory bowel dz
- caution if renal impairment
Adverse Reactions
Serious
- nephrotoxicity
- ototoxicity, auditory
- ototoxicity, vestibular
- neurotoxicity
- neuromuscular blockade
- malabsorption syndrome (prolonged use)
- superinfection (prolonged use)
- enterocolitis
Common
Pharmacology
- Half-life: Unknown
- Metabolism: CYP450
- Excretion: Feces
Mechanism of Action
Bactericidal and amebicidal. Paromomycin binds to bacterial 30S ribosomal subunit, inhibiting protein synthesis; it suppresses urease producing bacteria, reducing ammonia absorption from gut
Comments
See Also
References
UpToDate, Epocrates