Calcium gluconate: Difference between revisions
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**>50 years old: 1200 mg/day PO (divided q8-12hr) | **>50 years old: 1200 mg/day PO (divided q8-12hr) | ||
**Pregnant or breastfeeding patient: 1000 mg/day PO (divided q8-12hr) | **Pregnant or breastfeeding patient: 1000 mg/day PO (divided q8-12hr) | ||
*[[Hypocalcemia]] | |||
**Mild (Calcium 1-1.2 mmol/L) | |||
***1-3 g/day PO in divided doses | |||
***1-2 g IV over 2 hours | |||
**Severe (Calcium < 1 mmol/L) | |||
***without seizure or tetany: 0.5 mg/kg/hr IV, may be increased to 2 mg/kg/hr | |||
***Hypocalcemic tetany: | |||
****100-300 mg elemental calcium (~3g calcium gluconate) IV over 5-10 min | |||
****Followed by continuous IV infusion at 0.5 mg/kg/hr | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
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==Contraindications== | ==Contraindications== | ||
* | *Hypersensitivity | ||
*Hypercalcemia | |||
*Digoxin poisoning | |||
==Adverse Reactions== | ==Adverse Reactions== | ||
*Frequency not defined | |||
*Bradycardia | |||
*Constipation | |||
*Headache | |||
==Pharmacology== | ==Pharmacology== | ||
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*Metabolism: | *Metabolism: | ||
**Absorption requires Vitamin D | **Absorption requires Vitamin D | ||
**Absorption is increased with acidic condition; thus, administer 1-2 hr after meals | |||
**~45% protein bound (primarily to albumin) | **~45% protein bound (primarily to albumin) | ||
*Excretion: Feces (80%), Urine (20%) | *Excretion: Feces (80%), Urine (20%) | ||
Revision as of 09:54, 31 July 2015
General
- Type:
- Dosage Forms: IV/PO
- Common Trade Names: Calcium Gluconate
Adult Dosing
- Calcium Supplementation
- 19-50 years old: 1000 mg/day PO (divided q8-12hr)
- >50 years old: 1200 mg/day PO (divided q8-12hr)
- Pregnant or breastfeeding patient: 1000 mg/day PO (divided q8-12hr)
- Hypocalcemia
- Mild (Calcium 1-1.2 mmol/L)
- 1-3 g/day PO in divided doses
- 1-2 g IV over 2 hours
- Severe (Calcium < 1 mmol/L)
- without seizure or tetany: 0.5 mg/kg/hr IV, may be increased to 2 mg/kg/hr
- Hypocalcemic tetany:
- 100-300 mg elemental calcium (~3g calcium gluconate) IV over 5-10 min
- Followed by continuous IV infusion at 0.5 mg/kg/hr
- Mild (Calcium 1-1.2 mmol/L)
Pediatric Dosing
Special Populations
- Pregnancy Rating: Class C
- Lactation risk: Use with caution
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Hypersensitivity
- Hypercalcemia
- Digoxin poisoning
Adverse Reactions
- Frequency not defined
- Bradycardia
- Constipation
- Headache
Pharmacology
- Half-life:
- Metabolism:
- Absorption requires Vitamin D
- Absorption is increased with acidic condition; thus, administer 1-2 hr after meals
- ~45% protein bound (primarily to albumin)
- Excretion: Feces (80%), Urine (20%)
- Mechanism of Action: Bone mineral component; cofactor in enzymatic reactions, essential for neurotrasmission, muscle contraction, and many signal transduction pathways.