Baclofen toxicity: Difference between revisions
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*Indications include MS, muscle spasticity pain | *Indications include MS, muscle spasticity pain | ||
*GABAb receptor agonist | *GABAb receptor agonist | ||
*Most excretion is renal | |||
==Toxicity== | ==Toxicity== | ||
Revision as of 23:56, 16 July 2015
Background
- Indications include MS, muscle spasticity pain
- GABAb receptor agonist
- Most excretion is renal
Toxicity
- N/V
- Drowziness, dizziness
- Seizures, delirium, AMS, coma
- Bradycardia, hypotension OR HTN, respiratory compromise
- Hypothermia
Management
- Diagnosis of exclusion
- Activated charcoal for recent ingestion
- Supportive care:
- IV fluids, respiratory care
- Vasopressors for persistent hypotension
- Benzodiazepines for seizures
- Hemodialysis for very severe toxicity
References
- Jung, M. “Baclofen Overdoses”. Maryland Poison Center, University of Maryland School of Pharmacy. www.mdpoison.com Accessed April 29th, 2014.
- Nicola Y Leung, Ian M Whyte, Geoffrey K Isbister Baclofen overdose: defining the spectrum of toxicity. Emerg Med Australas: 2006, 18(1);77-82