Vitamin K: Difference between revisions
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==Adult Dosing== | ==Adult Dosing== | ||
'''vitamin K deficiency hypoprothrombinemia''': 2.5-25 mg PO qd prn; Max: 25 mg/dose | |||
'''anticoagulant induced hypoprothrombinemia''': 10 mg PO x1; Max: 25 mg/dose | |||
'''warfarin stabilization''': 100 mcg PO qd-bid | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
Revision as of 20:52, 30 June 2015
Disambiguation: See ketamine for street name "vitamin K"
General
- Type: Vitamin
- Dosage Forms: 100 mcg; 5 mg; SC; IM; IV; PO
- Common Trade Names: Generic and Mephyton, K1-1000, Novaplus Vitamin K1
Adult Dosing
vitamin K deficiency hypoprothrombinemia: 2.5-25 mg PO qd prn; Max: 25 mg/dose
anticoagulant induced hypoprothrombinemia: 10 mg PO x1; Max: 25 mg/dose
warfarin stabilization: 100 mcg PO qd-bid
Pediatric Dosing
- Neonatal deficiency (hemorrhagic disease of the newborn): 1mg vitamin K SC for avoidance of anaphylaxis (IV), hematoma (IM). FFP for serious cases.
Special Populations
- Pregnancy Rating: C
- Lactation risk: Safe
- Renal Dosing
- Adult: not defined
- Pediatric: not defined
- Hepatic Dosing
- Adult: adjust dose amount
- Pediatric: adjust dose amount
Contraindications
- Allergy to class/drug
- hereditary hypoprothrombinemia
- overanticoagulation due to heparins
- caution in neonates
Adverse Reactions
Serious
- anticoagulant resistance
- hypersensitivity rxn, severe or life-threatening (SC, IM, or IV use)
- anaphylaxis (SC, IM, or IV use)
- hyperbilirubinemia (neonates)
- hemolytic anemia (neonates)
Common
- taste changes (SC, IM, or IV use)
- flushing (SC, IM, or IV use)
- injection site hematoma
- injection site pain
Pharmacology
- Half-life: unknown
- Metabolism: liver, CYP450: unknown
- Excretion: urine, bile
- Mechanism of Action: Used by liver for synthesis of some coagulation factors (II,VII,IX,X,C,S). Timing in the synthesis of these factors impacts reversal of elevated INR (~4 hours: F-VII, ~24 hours: F-II). [Various: Lange Clinical. Tintinalli]