Vitamin K: Difference between revisions
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==Contraindications== | ==Contraindications== | ||
*Allergy to class/drug | *Allergy to class/drug | ||
*hereditary hypoprothrombinemia | |||
*overanticoagulation due to heparins | |||
*caution in neonates | |||
==Adverse Reactions== | ==Adverse Reactions== | ||
Revision as of 20:42, 30 June 2015
Disambiguation: See ketamine for street name "vitamin K"
General
- Type: Vitamin
- Dosage Forms: IV, IM, SC, PO
- Common Trade Names: Generic and Mephyton, K1-1000, Novaplus Vitamin K1
Adult Dosing
Pediatric Dosing
- Neonatal deficiency (hemorrhagic disease of the newborn): 1mg vitamin K SC for avoidance of anaphylaxis (IV), hematoma (IM). FFP for serious cases.
Special Populations
- Pregnancy Rating: C
- Lactation risk: Safe
- Renal Dosing
- Adult: not defined
- Pediatric: not defined
- Hepatic Dosing
- Adult: adjust dose amount
- Pediatric: adjust dose amount
Contraindications
- Allergy to class/drug
- hereditary hypoprothrombinemia
- overanticoagulation due to heparins
- caution in neonates
Adverse Reactions
Serious
- anticoagulant resistance
- hypersensitivity rxn, severe or life-threatening (SC, IM, or IV use)
- anaphylaxis (SC, IM, or IV use)
- hyperbilirubinemia (neonates)
- hemolytic anemia (neonates)
Common
- taste changes (SC, IM, or IV use)
- flushing (SC, IM, or IV use)
- injection site hematoma
- injection site pain
Pharmacology
- Half-life: unknown
- Metabolism: liver, CYP450: unknown
- Excretion: urine, bile
- Mechanism of Action: Used by liver for synthesis of some coagulation factors (II,VII,IX,X,C,S). Timing in the synthesis of these factors impacts reversal of elevated INR (~4 hours: F-VII, ~24 hours: F-II). [Various: Lange Clinical. Tintinalli]