Vitamin K: Difference between revisions
| Line 14: | Line 14: | ||
==Special Populations== | ==Special Populations== | ||
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: | *[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C | ||
*[[Lactation risk categories|Lactation risk]]: | *[[Lactation risk categories|Lactation risk]]: Safe | ||
*Renal Dosing | *Renal Dosing | ||
**Adult | **Adult: not defined | ||
**Pediatric | **Pediatric: not defined | ||
*Hepatic Dosing | *Hepatic Dosing | ||
**Adult | **Adult: adjust dose amount | ||
**Pediatric | **Pediatric: adjust dose amount | ||
==Contraindications== | ==Contraindications== | ||
Revision as of 20:39, 30 June 2015
Disambiguation: See ketamine for street name "vitamin K"
General
- Type: Vitamin
- Dosage Forms: IV, IM, SC, PO
- Common Trade Names: Generic and Mephyton, K1-1000, Novaplus Vitamin K1
Adult Dosing
Pediatric Dosing
- Neonatal deficiency (hemorrhagic disease of the newborn): 1mg vitamin K SC for avoidance of anaphylaxis (IV), hematoma (IM). FFP for serious cases.
Special Populations
- Pregnancy Rating: C
- Lactation risk: Safe
- Renal Dosing
- Adult: not defined
- Pediatric: not defined
- Hepatic Dosing
- Adult: adjust dose amount
- Pediatric: adjust dose amount
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
Common
Pharmacology
- Half-life: unknown
- Metabolism: liver, CYP450: unknown
- Excretion: urine, bile
- Mechanism of Action: Used by liver for synthesis of some coagulation factors (II,VII,IX,X,C,S). Timing in the synthesis of these factors impacts reversal of elevated INR (~4 hours: F-VII, ~24 hours: F-II). [Various: Lange Clinical. Tintinalli]