Vitamin K: Difference between revisions
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==General== | ==General== | ||
Vitamin K in the ED: | |||
# Numbered list item Reversal of elevated INR | |||
*Type: | *Type: | ||
*Dosage Forms: | *Dosage Forms: | ||
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==Pediatric Dosing== | ==Pediatric Dosing== | ||
* Neonatal deficiency: May underlie hemorrhagic disease of the newborn. 1mg vitamin K SC for avoidance of anaphylaxis (IV), hematoma (IM). FFP for serious cases. | |||
==Special Populations== | ==Special Populations== | ||
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*Metabolism: | *Metabolism: | ||
*Excretion: | *Excretion: | ||
*Mechanism of Action: | *Mechanism of Action: Used by liver for synthesis of some coagulation factors (II,VII,IX,X,C,S). Timing in the synthesis of these factors impacts reversal of elevated INR (~4 hours: F-VII, ~24 hours: F-II). [Various: Lange Clinical. Tintinalli] | ||
==Comments== | ==Comments== | ||
Revision as of 16:36, 29 June 2015
General
Vitamin K in the ED:
- Numbered list item Reversal of elevated INR
- Type:
- Dosage Forms:
- Common Trade Names:
Adult Dosing
Pediatric Dosing
- Neonatal deficiency: May underlie hemorrhagic disease of the newborn. 1mg vitamin K SC for avoidance of anaphylaxis (IV), hematoma (IM). FFP for serious cases.
Special Populations
- Pregnancy Rating:
- Lactation risk:
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
Common
Pharmacology
- Half-life:
- Metabolism:
- Excretion:
- Mechanism of Action: Used by liver for synthesis of some coagulation factors (II,VII,IX,X,C,S). Timing in the synthesis of these factors impacts reversal of elevated INR (~4 hours: F-VII, ~24 hours: F-II). [Various: Lange Clinical. Tintinalli]