Midazolam: Difference between revisions
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==General== | ==General== | ||
*Type: [[Benzodiazepines]] | *Type: [[Benzodiazepines]] | ||
*Dosage Forms: | *Dosage Forms: IV | ||
*Common Trade Names: Versed | *Common Trade Names: Versed | ||
==Adult Dosing== | ==Adult Dosing== | ||
*2mg IV | *Anxiolysis/sedation: 1-2mg IV push | ||
*ICU Sedation: | |||
**Load: 10-50mcg/kg IV infusion | |||
**Maintenance: 20-100 mcg/kg/hr infusion | |||
**Use with standardized sedation protocol for titration | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
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==Special Populations== | ==Special Populations== | ||
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: | *[[Drug Ratings in Pregnancy|Pregnancy Rating]]: D | ||
*Lactation: | **Maternal use shortly before delivery associated with floppy infant syndrome | ||
*Renal Dosing | *Lactation: Distributed in breast milk, use with caution | ||
*Renal Dosing: | |||
**Adult | **Adult | ||
**Pediatric | **Pediatric | ||
*Hepatic Dosing | *Hepatic Dosing: | ||
**Adult | **Adult | ||
**Pediatric | **Pediatric | ||
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==Adverse Reactions== | ==Adverse Reactions== | ||
===Serious=== | ===Serious=== | ||
*Apnea | |||
*Hypopnea | |||
===Common=== | ===Common=== | ||
*Drowsiness | |||
*Nausea/vomiting | |||
==Pharmacology== | ==Pharmacology== | ||
*Half-life: | *Half-life: 1.8-6.4 hr | ||
*Metabolism: | *Metabolism: Metabolized in liver by CYP3A4 to active metabolite alpha1-hydroxymidazolam | ||
*Excretion: | *Excretion: Renal | ||
*Mechanism of Action: | *Mechanism of Action: CNS depressant. Acts at GABA receptor to increase frequency of chloride channel opening, causing hyperpolarization and stabilization of neuronal membrane. | ||
==See Also== | ==See Also== | ||
[[Benzodiazepines]] | |||
==Sources== | ==Sources== | ||
Micromedex | |||
<references/> | <references/> | ||
[[Category:Drugs]] | [[Category:Drugs]] | ||
Revision as of 18:31, 15 June 2015
See critical care quick reference for drug doses by weight.
General
- Type: Benzodiazepines
- Dosage Forms: IV
- Common Trade Names: Versed
Adult Dosing
- Anxiolysis/sedation: 1-2mg IV push
- ICU Sedation:
- Load: 10-50mcg/kg IV infusion
- Maintenance: 20-100 mcg/kg/hr infusion
- Use with standardized sedation protocol for titration
Pediatric Dosing
See critical care quick reference for drug doses by weight.
Special Populations
- Pregnancy Rating: D
- Maternal use shortly before delivery associated with floppy infant syndrome
- Lactation: Distributed in breast milk, use with caution
- Renal Dosing:
- Adult
- Pediatric
- Hepatic Dosing:
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- Apnea
- Hypopnea
Common
- Drowsiness
- Nausea/vomiting
Pharmacology
- Half-life: 1.8-6.4 hr
- Metabolism: Metabolized in liver by CYP3A4 to active metabolite alpha1-hydroxymidazolam
- Excretion: Renal
- Mechanism of Action: CNS depressant. Acts at GABA receptor to increase frequency of chloride channel opening, causing hyperpolarization and stabilization of neuronal membrane.
See Also
Sources
Micromedex