Template:Cryptococcus Meningitis: Difference between revisions
(Add pediatric cryptococcal meningitis dosing) |
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===Meningitis (not AIDs associated)=== | ===Meningitis (not AIDs associated)=== | ||
*Amphotericin B 0.7-1mg/kg IV q24hrs | *{{AntibioticDose|disease=Cryptococcosis|drug=Amphotericin B|dose=0.7-1mg/kg IV q24hrs|context=Meningitis not AIDS with Flucytosine x 4 weeks|population=Adult}} '''AND''' Flucytosine 25mg/kg PO q6hrs x 4 weeks | ||
**Followed by Fluconazole 400mg PO q24hrs x 8 weeks | **Followed by {{AntibioticDose|disease=Cryptococcosis|drug=Fluconazole|dose=400mg PO q24hrs x 8 weeks|context=Meningitis consolidation not AIDS|population=Adult}} | ||
===Meningitis (with AIDS)=== | ===Meningitis (with AIDS)=== | ||
* | *{{AntibioticDose|disease=Cryptococcosis|drug=Amphotericin B|dose=0.7-1mg/kg IV q24hrs|context=Meningitis with AIDS with Flucytosine x 2 weeks|population=Adult}} '''AND''' [[Flucytosine]] 25mg/kg PO q6hrs x 2 weeks | ||
**Followed by Fluconazole 400mg PO q24hrs x 8 weeks | **Followed by {{AntibioticDose|disease=Cryptococcosis|drug=Fluconazole|dose=400mg PO q24hrs x 8 weeks|context=Meningitis consolidation with AIDS|population=Adult}} | ||
*Initiation of HAART is delayed by 2 to 10 weeks to minimize the risk of immune reconstitution syndrome | *Initiation of HAART is delayed by 2 to 10 weeks to minimize the risk of immune reconstitution syndrome | ||
===Pediatric Cryptococcal Meningitis=== | |||
*{{AntibioticDose|disease=Cryptococcosis|drug=Amphotericin B|dose=0.7-1mg/kg IV daily x 2-4 weeks|context=Pediatric Meningitis|population=Pediatric}} + Flucytosine 25mg/kg PO q6hrs | |||
**Followed by {{AntibioticDose|disease=Cryptococcosis|drug=Fluconazole|dose=6-12mg/kg PO daily x 8 weeks (max 400mg)|context=Pediatric Consolidation|population=Pediatric}} | |||
Latest revision as of 13:21, 20 March 2026
Meningitis (not AIDs associated)
- Amphotericin B 0.7-1mg/kg IV q24hrs AND Flucytosine 25mg/kg PO q6hrs x 4 weeks
- Followed by Fluconazole 400mg PO q24hrs x 8 weeks
Meningitis (with AIDS)
- Amphotericin B 0.7-1mg/kg IV q24hrs AND Flucytosine 25mg/kg PO q6hrs x 2 weeks
- Followed by Fluconazole 400mg PO q24hrs x 8 weeks
- Initiation of HAART is delayed by 2 to 10 weeks to minimize the risk of immune reconstitution syndrome
Pediatric Cryptococcal Meningitis
- Amphotericin B 0.7-1mg/kg IV daily x 2-4 weeks + Flucytosine 25mg/kg PO q6hrs
- Followed by Fluconazole 6-12mg/kg PO daily x 8 weeks (max 400mg)