Quinine: Difference between revisions
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===Indications by Disease=== | ===Indications by Disease=== | ||
{{#ask: [[Has DrugName::Quinine]] [[Has Population::Adult]] | {{#ask: [[Has DrugName::Quinine]] [[Has Population::Adult]] | ||
|?Treats disease=Disease | |?Treats disease=Disease | ||
|?Has Dose=Dose | |?Has Dose=Dose | ||
|?Has Context=Context | |?Has Context=Context | ||
|format=table | |format=table | ||
|limit=50 | |limit=50 | ||
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|headers=show | |headers=show | ||
|sort=Treats disease | |sort=Treats disease | ||
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===Indications by Disease=== | ===Indications by Disease=== | ||
{{#ask: [[Has DrugName::Quinine]] [[Has Population::Pediatric]] | {{#ask: [[Has DrugName::Quinine]] [[Has Population::Pediatric]] | ||
|?Treats disease=Disease | |?Treats disease=Disease | ||
|?Has Dose=Dose | |?Has Dose=Dose | ||
|?Has Context=Context | |?Has Context=Context | ||
|format=table | |format=table | ||
|limit=50 | |limit=50 | ||
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*Blindness | *Blindness | ||
*Deafness | *Deafness | ||
===Common=== | ===Common=== | ||
*Cinchonism | *Cinchonism | ||
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*Metabolism: Liver 80%, CYP450 | *Metabolism: Liver 80%, CYP450 | ||
*Excretion: Urine | *Excretion: Urine | ||
*Mechanism of Action: | *Mechanism of Action: Unknown | ||
==Administration== | ==Administration== | ||
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==References== | ==References== | ||
*Epocrates | *Epocrates | ||
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[[Category:Pharmacology]] | [[Category:Pharmacology]] | ||
[[Category:ID]] | [[Category:ID]] | ||
Latest revision as of 12:10, 20 March 2026
General
- Type: Antimalarial
- Dosage Forms: PO 324 (IM and IV formulations available outside US)
- Common Trade Names: Qualaquin
Adult Dosing
Indications by Disease
| Disease | Dose | Context |
|---|---|---|
| Babesiosis | 650mg TID | Severe parasitemia with Clindamycin use IV for severe |
| Malaria | 648mg PO q8h x 7 days | Uncomplicated malaria, use with doxycycline or clindamycin |
Pediatric Dosing
Indications by Disease
| Disease | Dose | Context |
|---|---|---|
| Babesiosis | 8mg/kg PO q8h x 7-10 days (Max: 648mg/dose) | Severe parasitemia with Clindamycin |
| Malaria | 30mg/kg/day PO q8h x 3-7 days (Max: 648mg/dose) | Uncomplicated malaria, use with clindamycin |
Special Populations
- Pregnancy Rating: C
- Lactation: Probably safe
- Renal Dosing
- Adult
- Severe chronic renal failure: 648mg PO x 1 then 324mg PO q12h
- If on HD give after dialysis
- Pediatric
- Not defined
- Adult
- Hepatic Dosing
- Adult and Pediatric
- No adjustment for Child-Pugh Class A or B
- Avoid in Child-Pugh Class C
- Adult and Pediatric
Contraindications
Black Box Warnings
General
- Allergy to class/drug
- Allergy to mefloquine or quinidine
- Black water fever
- ITP/TTP/HUS
- Thrombocytopenia
- Glucose-6-Phosphate Deficiency (G6PD)
- Myasthenia gravis
- Optic neuritis
- QT prolongation/Congenital long QT syndrome
- Electrolyte abnormalities
- Bradycardia
- Ventricular arrhythmias
- CHF
- Recent MI
Caution
- Torsades de pointes
- Atrial fibrillation/Atrial flutter
- Pregnancy
- Hepatic impairment
Adverse Reactions
Serious
- Cinchonism
- QT prolongation
- Torsades de pointes
- Anaphylaxis
- Angioedema
- Bronchospasm
- Thrombocytopenia
- TTP/HUS
- Hemolytic anemia
- Black water fever
- Stevens-Johnson syndrome and toxic epidermal necrolysis
- Intestinal nephritis
- Renal impairment
- Hepatitis
- Leukopenia
- Neutropenia
- DIC
- Hypoglycemia
- Myasthenia gravis exacerbation
- Lupus
- Optic neuritis
- Blindness
- Deafness
Common
- Cinchonism
- Headache
- Vasodilation
- Diaphoresis
- Nausea/Vomiting
- Tinnitus
- Impaired hearing
- Vertigo
- Visual impairment
- Fever
- Flushing
- asthenia
- Rash
- Pruritus
- Urticaria
- Diarrhea
- Abdominal pain
- Photosensitivity
Pharmacology
- Half-life: 9-12 hours
- Metabolism: Liver 80%, CYP450
- Excretion: Urine
- Mechanism of Action: Unknown
Administration
- Give with food
Toxicity
- Mild
- Nausea
- Vomiting
- Tinnitus
- Vertigo
- Deafness
- Severe
- Ataxia
- Convulsions
- Coma
- QRS/QT prolongation
- Arrhythmia
- Retinal Toxicity
- Blurry vision
- Impaired visual fields
- Blindness
See Also
References
- Epocrates