Pyrimethamine: Difference between revisions
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==Adult Dosing== | ==Adult Dosing== | ||
*25-200mg PO (weekly or daily, depending on indication), in combination with other antimicrobials | |||
===Indications by Disease=== | ===Indications by Disease=== | ||
{{#ask: [[Has DrugName::Pyrimethamine]] [[Has Population::Adult]] | {{#ask: [[Has DrugName::Pyrimethamine]] [[Has Population::Adult]] | ||
|?Treats disease=Disease | |?Treats disease=Disease | ||
|?Has Dose=Dose | |?Has Dose=Dose | ||
|?Has Context=Context | |?Has Context=Context | ||
|format=table | |format=table | ||
|limit=50 | |limit=50 | ||
|mainlabel=- | |mainlabel=- | ||
|headers=show | |headers=show | ||
|sort=Treats disease | |sort=Treats disease | ||
}} | }} | ||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
*1-3mg/kg PO | |||
===Indications by Disease=== | ===Indications by Disease=== | ||
{{#ask: [[Has DrugName::Pyrimethamine]] [[Has Population::Pediatric]] | {{#ask: [[Has DrugName::Pyrimethamine]] [[Has Population::Pediatric]] | ||
|?Treats disease=Disease | |?Treats disease=Disease | ||
|?Has Dose=Dose | |?Has Dose=Dose | ||
|?Has Context=Context | |?Has Context=Context | ||
|format=table | |format=table | ||
|limit=50 | |limit=50 | ||
|mainlabel=- | |mainlabel=- | ||
|headers=show | |headers=show | ||
|sort=Treats disease | |sort=Treats disease | ||
}} | }} | ||
Latest revision as of 02:39, 20 March 2026
Note: As of 2015, pyrimethamine is only available in the US through a special pharmacy program[1]
Administration
- Type: Antiparasitic, indicated for treatment and prophylaxis of Toxoplasmosis and malaria
- Dosage Forms:
- Routes of Administration: Oral
- Common Trade Names:
Adult Dosing
- 25-200mg PO (weekly or daily, depending on indication), in combination with other antimicrobials
Indications by Disease
| Disease | Dose | Context |
|---|---|---|
| Toxoplasmosis | 200mg PO load then 50mg PO q24hrs x 4 weeks | Immunocompetent with Leucovorin and Sulfadiazine |
| Toxoplasmosis | 200mg PO load then 75mg PO q24hrs x 4-8 weeks | Immunosuppressed |
Pediatric Dosing
- 1-3mg/kg PO
Indications by Disease
| Disease | Dose | Context |
|---|---|---|
| Toxoplasmosis | 2mg/kg/day PO x 2 days then 1mg/kg/day x 2-6 months, then 1mg/kg MWF | Congenital/Pediatric |
Special Populations
- Pregnancy Rating: C
- Lactation risk: Infant risk minimal
- Renal dosing:
Contraindications
- Allergy to class/drug
- megaloblastic anemia due to folate deficiency
Adverse Reactions
Serious
- SJS, TEN
- Pancytopenia, leukopenia, thrombocytopenia, megaloblastic anemia
Common
- Rash
Pharmacology
- Half-life: 52-97 hours
- Metabolism: Hepatic
- Excretion:
Mechanism of Action
- Blocks protozoal dihydrofolate reductase, inhibiting nucleic acid synthesis