Paromomycin: Difference between revisions
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==Administration== | ==Administration== | ||
*Class:[[Is DrugClass::Aminoglycoside]] | |||
*Type: Amebicide | *Type: Amebicide | ||
*Dosage Forms: 250 | *Dosage Forms: 250 | ||
| Line 6: | Line 7: | ||
==Adult Dosing== | ==Adult Dosing== | ||
===Intestinal [[amebiasis]]=== | |||
**Give | *25-35mg/kg/day PO divided tid x5-10 days | ||
**Give with food | |||
===[[Hepatic encephalopathy]]=== | |||
**Give | *adjunct treatment: 1000mg PO QID x5-6 days | ||
**Give with food | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
===Intestinal [[amebiasis]]=== | |||
*25-35mg/kg/day PO divided tid x5-10 days | |||
==Special Populations== | ==Special Populations== | ||
| Line 29: | Line 33: | ||
*GI obstruction | *GI obstruction | ||
*caution if ulcerative colitis | *caution if ulcerative colitis | ||
*caution if inflammatory bowel | *caution if inflammatory bowel disease | ||
*caution if renal impairment | *caution if renal impairment | ||
| Line 43: | Line 47: | ||
*enterocolitis | *enterocolitis | ||
===Common=== | ===Common=== | ||
*nausea | *[[nausea]] | ||
*abdominal cramps | *abdominal cramps | ||
*diarrhea | *[[diarrhea]] | ||
==Pharmacology== | ==Pharmacology== | ||
| Line 61: | Line 65: | ||
==References== | ==References== | ||
<references/> | <references/> | ||
UpToDate, Epocrates | |||
[[Category:Pharmacology]] | |||
[[Category:ID]] | |||
Latest revision as of 15:12, 18 July 2025
Administration
- Class:Aminoglycoside
- Type: Amebicide
- Dosage Forms: 250
- Routes of Administration: Oral
- Common Trade Names: Humatin
Adult Dosing
Intestinal amebiasis
- 25-35mg/kg/day PO divided tid x5-10 days
- Give with food
Hepatic encephalopathy
- adjunct treatment: 1000mg PO QID x5-6 days
- Give with food
Pediatric Dosing
Intestinal amebiasis
- 25-35mg/kg/day PO divided tid x5-10 days
Special Populations
- Poorly absorbed when given orally
- Use during pregnancy has limited data
Renal Dosing
- No change in dosing
Hepatic Dosing
- No change in dosing
Contraindications
- Allergy to class/drug
- GI obstruction
- caution if ulcerative colitis
- caution if inflammatory bowel disease
- caution if renal impairment
Adverse Reactions
Serious
- nephrotoxicity
- ototoxicity, auditory
- ototoxicity, vestibular
- neurotoxicity
- neuromuscular blockade
- malabsorption syndrome (prolonged use)
- superinfection (prolonged use)
- enterocolitis
Common
Pharmacology
- Half-life: Unknown
- Metabolism: CYP450
- Excretion: Feces
Mechanism of Action
Bactericidal and amebicidal. Paromomycin binds to bacterial 30S ribosomal subunit, inhibiting protein synthesis; it suppresses urease producing bacteria, reducing ammonia absorption from gut
Comments
See Also
References
UpToDate, Epocrates