Steroid-induced psychosis: Difference between revisions

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==Clinical Features==
==Clinical Features==
 
*Wide range of possible psychiatric symptoms
**Delusions or hallucinations
**Euphoria
**Mania, depression, anxiety
**Severe cases may present with suicidal ideation, violence, aggression


==Differential Diagnosis==
==Differential Diagnosis==

Revision as of 13:02, 13 March 2024

Background

  • In 718 hospitalized patients, 4.6% of patients on 40 mg or higher per day of prednisone had psychiatric symptoms[1]
    • Incidence rises to 18.4% for patients receiving more than 80 mg per day
  • Mechanism unproven but thought to be increased dopamine due to induction of tyrosin hydroxylase by corticosteroids[2]

Clinical Features

  • Wide range of possible psychiatric symptoms
    • Delusions or hallucinations
    • Euphoria
    • Mania, depression, anxiety
    • Severe cases may present with suicidal ideation, violence, aggression

Differential Diagnosis

Evaluation

Workup

Diagnosis

Management

Disposition

See Also

External Links

References

  1. Acute adverse reactions to prednisone in relation to dosage. Clin Pharmacol Ther. 1972;13:694-698.
  2. J Pharm Technol. 2021 Apr; 37(2): 120–126. Published online 2020 Dec 2.