Acute leukemia: Difference between revisions

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== [[Acute myeloid leukemia]]  ==
*[[Acute myeloid leukemia]]  
 
*[[Acute lymphocytic leukemia]]
=== Background  ===
 
*aka Acute myelogenous leukemia or non-lymphocytic leukemia
*Most common acute leukemia in adults (around 80% of cases)
*65yo median age of diagnosis, Male:Female 5:3
*characterized by clonal proliferation of myeloid precursors(blast cells >20% in the periphery)
 
=== Diagnosis  ===
 
*Presents with anemia, neutropenia, thrombocytopenia,
*weakness, easy fatigability, infections, gingival bleeding/enlargement, ecchymoses, epistaxis, menorrhagia
 
<br>
 
=== Work-Up  ===
 
*CXR
*CBC with peripheral smear
*Chem7, ca, mg, phos, Uric Acid, UA, LDH (to check for Tumor Lysis)
*LFTs, Coags, FDP, D-Dimer, Haptoglobin, Fibrinogen (to check for DIC)
*Get extra purple top for flow cytometry, especially before transfusion
 
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=== Treatment  ===
 
*Aggressive IV hydration
*If febrile, complete cultures and broad spectrum antibiotics
*Manage Complications
**see [[DIC]]
**see [[Leukostasis]]  
**see [[Tumor Lysis Syndrome]]
 
== [[Acute lymphocytic leukemia]] ==


=== Background  ===
=== Background  ===

Revision as of 19:52, 11 May 2015

Background

  • Characterized by proliferation of immature lymphoblast( >20% in periphery)
  • Less than 20% of acute leukemias in adults,
  • Most common form in children (see also Leukemia (Peds))
  • Highest incidence in 7th decade of life

Diagnosis

  • Lymphocytosis, neutropenia, anemia, thrombocytopenia,
  • Lymphadenopathy, hepatosplenomegaly
  • CNS and testes involvement common

DDX

  • Hodgkin and non-Hodgkin lymphomas

Work-Up

  • CXR
  • CBC with peripheral smear
  • Chem7, ca, mg, phos, Uric Acid, UA, LDH (to check for Tumor Lysis)
  • LFTs, Coags, FDP, D-Dimer, Haptoglobin, Fibrinogen (to check for DIC)
  • Get extra purple top for flow cytometry, especially before transfusion

Treatment


Source

Uptodate & MKSAP15

See Also

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