Enalapril: Difference between revisions
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==General== | ==General== | ||
*Type: | *Type: [[ACE inhibitor]] | ||
*Dosage Forms: | *Dosage Forms: 2.5, 5, 10, 20 | ||
*Common Trade Names: | *Common Trade Names: Vasotec, Epaned | ||
General information: | |||
* Doses > 40 mg/day rarely more effective | |||
* Decreased efficacy as mono therapy in african-american patients | |||
* Obtain Chem 10 if starting in ED to assess renal function | |||
==Adult Dosing== | ==Adult Dosing== | ||
* HTN: 10 - 40 mg PO Qday, max 40 mg/day | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
* 1 month -16 year old: 0.1 - 0.5 mg/kg/day PO divided q12 - 24h, max 40 mg/day | |||
==Special Populations== | ==Special Populations== | ||
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: | *[[Drug Ratings in Pregnancy|Pregnancy Rating]]: D | ||
*Lactation: | *Lactation: Probably Safe | ||
*Renal Dosing | *Renal Dosing | ||
**Adult | **Adult: CrCl < 30, start 2.5 mg qday, max 40 mg q/day | ||
**Pediatric | **Pediatric Cr Cl 10-50: decrease dose 25%, CrCl < 10: decrease dose 50% | ||
*Hepatic Dosing | *Hepatic Dosing | ||
**Adult | **Adult: Not defined | ||
**Pediatric | **Pediatric: Not defined | ||
==Contraindications== | ==Contraindications== | ||
*Allergy to class/drug | *Allergy to class/drug | ||
* hx of angioedema | |||
* pregnancy | |||
* caution if renal artery stenosis | |||
* caution if severe CHF | |||
* caution if renal impairment | |||
==Adverse Reactions== | ==Adverse Reactions== | ||
===Serious=== | ===Serious=== | ||
* angioedema | |||
* hypotension | |||
* hyperkalemia | |||
* renal impairment | |||
* hepatotoxicity | |||
* neutropenia | |||
*pancreatitis | |||
* steven johnson syndrome | |||
* fetal/neonatal harm | |||
* congenital malformations | |||
===Common=== | ===Common=== | ||
* dizziness | |||
* elevated Cr | |||
* headache | |||
*diarrhea | |||
* hypotension | |||
* abdominal pain | |||
* hyperkalemia | |||
==Pharmacology== | ==Pharmacology== | ||
*Half-life: | *Half-life: 12 hours | ||
*Metabolism: | *Metabolism: Liver | ||
*Excretion: | *Excretion: urine, feces | ||
*Mechanism of Action: | *Mechanism of Action: inhibits angiotensin converting enzyme, interferes with conversion of angiotensin 1 to angiotensin 2 | ||
==See Also== | ==See Also== | ||
Revision as of 02:50, 5 May 2015
General
- Type: ACE inhibitor
- Dosage Forms: 2.5, 5, 10, 20
- Common Trade Names: Vasotec, Epaned
General information:
- Doses > 40 mg/day rarely more effective
- Decreased efficacy as mono therapy in african-american patients
- Obtain Chem 10 if starting in ED to assess renal function
Adult Dosing
- HTN: 10 - 40 mg PO Qday, max 40 mg/day
Pediatric Dosing
- 1 month -16 year old: 0.1 - 0.5 mg/kg/day PO divided q12 - 24h, max 40 mg/day
Special Populations
- Pregnancy Rating: D
- Lactation: Probably Safe
- Renal Dosing
- Adult: CrCl < 30, start 2.5 mg qday, max 40 mg q/day
- Pediatric Cr Cl 10-50: decrease dose 25%, CrCl < 10: decrease dose 50%
- Hepatic Dosing
- Adult: Not defined
- Pediatric: Not defined
Contraindications
- Allergy to class/drug
- hx of angioedema
- pregnancy
- caution if renal artery stenosis
- caution if severe CHF
- caution if renal impairment
Adverse Reactions
Serious
- angioedema
- hypotension
- hyperkalemia
- renal impairment
- hepatotoxicity
- neutropenia
- pancreatitis
- steven johnson syndrome
- fetal/neonatal harm
- congenital malformations
Common
- dizziness
- elevated Cr
- headache
- diarrhea
- hypotension
- abdominal pain
- hyperkalemia
Pharmacology
- Half-life: 12 hours
- Metabolism: Liver
- Excretion: urine, feces
- Mechanism of Action: inhibits angiotensin converting enzyme, interferes with conversion of angiotensin 1 to angiotensin 2