Tromethamine: Difference between revisions
(Created page with "==Administration== *Type: Tham: 30 mEq/100 mL (500 mL) [latex free] *Dosage Forms: *Routes of Administration: IV *Common Trade Names: THAM ==Adult Dosing== *Estimated dose when buffer base deficit is known: IV: tromethamine dose (mL of 0.3 M solution) = body weight (kg) x base deficit (mEq/L) x 1.1. *Initial: 111 to 333 mL of 0.3 M solution (3.6 to 10.8 g); additional amounts may be required to control acidosis after arrest reversed. ==Pediatric Dosing== * Infants, Chi...") |
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==Adult Dosing== | ==Adult Dosing== | ||
===[[Metabolic acidosis]]=== | |||
*Estimated dose when buffer base deficit is known: IV: tromethamine dose (mL of 0.3 M solution) = body weight (kg) x base deficit (mEq/L) x 1.1. | *Estimated dose when buffer base deficit is known: IV: tromethamine dose (mL of 0.3 M solution) = body weight (kg) x base deficit (mEq/L) x 1.1. | ||
*Initial: 111 to 333 mL of 0.3 M solution (3.6 to 10.8 g); additional amounts may be required to control acidosis after arrest reversed. | *Initial: 111 to 333 mL of 0.3 M solution (3.6 to 10.8 g); additional amounts may be required to control acidosis after arrest reversed. | ||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
===[[Metabolic acidosis]]=== | |||
* Infants, Children, and Adolescents: IV: Empiric dosage calculation equation based upon base deficit: | * Infants, Children, and Adolescents: IV: Empiric dosage calculation equation based upon base deficit: | ||
* Dose (mL) of THAM = body weight (kg) x base deficit (mEq/L) x 1.1* | * Dose (mL) of THAM = body weight (kg) x base deficit (mEq/L) x 1.1* | ||
Latest revision as of 20:40, 7 December 2022
Administration
- Type: Tham: 30 mEq/100 mL (500 mL) [latex free]
- Dosage Forms:
- Routes of Administration: IV
- Common Trade Names: THAM
Adult Dosing
Metabolic acidosis
- Estimated dose when buffer base deficit is known: IV: tromethamine dose (mL of 0.3 M solution) = body weight (kg) x base deficit (mEq/L) x 1.1.
- Initial: 111 to 333 mL of 0.3 M solution (3.6 to 10.8 g); additional amounts may be required to control acidosis after arrest reversed.
Pediatric Dosing
Metabolic acidosis
- Infants, Children, and Adolescents: IV: Empiric dosage calculation equation based upon base deficit:
- Dose (mL) of THAM = body weight (kg) x base deficit (mEq/L) x 1.1*
Special Populations
Pregnancy Rating
- Unknown
Lactation risk
- Unknwon
Renal Dosing
- Adult: There are no dosage adjustments provided in the manufacturer’s labeling.
- Pediatric: There are no dosage adjustments provided in the manufacturer’s labeling.
Hepatic Dosing
- Adult: There are no dosage adjustments provided in the manufacturer’s labeling.
- Pediatric: There are no dosage adjustments provided in the manufacturer’s labeling.
Contraindications
- Allergy to class/drug
- Uremia or anuria; chronic respiratory acidosis (neonates); salicylate intoxication (neonates).
Adverse Reactions
Serious
- Extravasation: Vesicant; ensure proper needle or catheter placement prior to and during administration; avoid extravasation. May cause tissue inflammation, sloughing, and necrosis.
- Hypoglycemia: May cause hypoglycemia with rapid administration or extremely large doses; monitor serum blood glucose during and after therapy.
- Respiratory depression: Large doses may decrease respiratory ventilation due to increased blood pH and reduced CO2; adjust dose so that blood pH is not increased above normal. Monitor closely especially if patient not intubated. In patients with concomitant respiratory acidosis, use only with mechanical ventilation.
Common
Pharmacology
- Half-life:
- Metabolism: None known.
- Excretion: Urine (>75%) within 8 hours.
Mechanism of Action
- Acts as a proton acceptor, which combines with hydrogen ions, liberating bicarbonate buffer, to correct acidosis. It buffers both metabolic and respiratory acids, limiting carbon dioxide generation. Also an osmotic diuretic.