Zollinger-Ellison syndrome: Difference between revisions
Erdojjones (talk | contribs) |
Erdojjones (talk | contribs) |
||
| Line 8: | Line 8: | ||
*Hematemesis | *Hematemesis | ||
*Chronic diarrhea | *Chronic diarrhea | ||
*Steatorrhea | |||
*Postprandial abdominal pain | *Postprandial abdominal pain | ||
*Nausea | *Nausea | ||
Revision as of 23:30, 1 November 2022
Background
- Also known as "S-E syndrome"
- gastric neuroendocrine malignancy results in hypersecretion of hydrochloric acid by parietal cells
- Associated with peptic ulcers and diarrhea
- 60% malignant, only 20% resectable; 25% of gastrinoma patients have multiple endocrine neoplasia type I; >80% of gastrinomas found in gastrinoma triangle.
Clinical Features
- Hematemesis
- Chronic diarrhea
- Steatorrhea
- Postprandial abdominal pain
- Nausea
- Wheezes on auscultation
- Evidence of malnourishment and decreased oral intake
Differential Diagnosis
Evaluation
Workup
Diagnosis
Management
- Proton-Pump Inhibitors
- Somatostatin analog (Octreotide) if no improvement
- Direct inhibition of gastric secretion
- Surgical resection