Etomidate: Difference between revisions
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==Pharmacology== | ==Pharmacology== | ||
*Half-life: | *Half-life: GABA agonist | ||
*Metabolism: | *Metabolism: | ||
*Excretion: | *Excretion: | ||
Revision as of 15:28, 25 March 2015
See critical care quick reference for drug doses by weight.
General
- Type:
- Dosage Forms:
- Common Trade Names:
Adult Dosing
RSI
- 0.3 mg/kg bolus IV
- Standard dose = 20mg
Procedural Sedation
- 0.15 mg/kg bolus IV
- Standard dose = 10mg)
Pediatric Dosing
See critical care quick reference for drug doses by weight.
RSI
- 0.3 mg/kg bolus IV
- Max: 20mg
Procedural Sedation
- (0.15 mg/kg bolus IV
- Max: 10mg
Special Populations
- Pregnancy Rating:
- Lactation:
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
Adverse Reactions
- Myoclonus
- Nausea/Vomiting
- Pain at injection site
Controversy
"The available evidence suggests that etomidate suppresses adrenal function transiently without demonstrating a significant effect on mortality. However, no studies to date have been powered to detect a difference in hospital, ventilator, or ICU length of stay or in mortality."[1]
Pharmacology
- Half-life: GABA agonist
- Metabolism:
- Excretion:
- Mechanism of Action:
See Also
Sources
- ↑ *Hohl CM, Kelly-Smith CH,Yeung TC, Sweet DD, Doyle-Waters MM, Schulzer M. The effect of a bolus dose of Etomidate on cortisol levels, mortality, and health services utilization: a systematic review. Ann Emerg Med. 2010;56(2):105-113.