Eosinophilia: Difference between revisions
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==Background== | ==Background== | ||
*Defined usually as peripheral eosinophil count >0.5 x 10<sup>9</sup>/L | *Defined usually as peripheral eosinophil count >0.5 x 10<sup>9</sup>/L | ||
*Eosinophils | *Eosinophils normally comprise <7% of total WBC count | ||
==Clinical Features== | ==Clinical Features== | ||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
*[[Allergic reaction]] or other | *[[Allergic reaction]] or other hypersensitivity/atopic state | ||
**[[Urticaria]], [[atopic dermatitis]], [[asthma]], drug reaction/hypersensitivity | **[[Urticaria]], [[atopic dermatitis]], [[asthma]], drug reaction/hypersensitivity | ||
*[[DRESS syndrome]] | *[[DRESS syndrome]], drug-induced | ||
*[[Parasitic infection]] | *[[Parasitic infection]] | ||
*[[Coccidioidomycosis]] and other fungal infections | *[[Coccidioidomycosis]] and other [[fungal infections]] | ||
*Malignancy (e.g. [[lymphoma]], eosinophilic [[leukemia]]) | *Malignancy (e.g. [[lymphoma]], eosinophilic [[leukemia]]) | ||
*Skin disorders (e.g. [[bullous pemphigoid]], dermatitis herpetiformis) | *Skin disorders (e.g. [[bullous pemphigoid]], dermatitis herpetiformis) | ||
*[[Adrenal insufficiency]] | *[[Adrenal insufficiency]] | ||
*Connective tissue disease (e.g. [[Churg-Strauss syndrome]]) | *[[Connective tissue disease]] (e.g. [[Churg-Strauss syndrome]]) | ||
*Interstitial nephritis | *Interstitial nephritis | ||
*[[Arsenic]] | *[[Arsenic]], [[gold toxicity]] | ||
==Evaluation== | ==Evaluation== | ||
*CBC with differential | |||
==Management== | ==Management== | ||
*Directed at underlying cause | |||
==Disposition== | ==Disposition== | ||
Latest revision as of 17:04, 12 January 2022
Background
- Defined usually as peripheral eosinophil count >0.5 x 109/L
- Eosinophils normally comprise <7% of total WBC count
Clinical Features
Differential Diagnosis
- Allergic reaction or other hypersensitivity/atopic state
- Urticaria, atopic dermatitis, asthma, drug reaction/hypersensitivity
- DRESS syndrome, drug-induced
- Parasitic infection
- Coccidioidomycosis and other fungal infections
- Malignancy (e.g. lymphoma, eosinophilic leukemia)
- Skin disorders (e.g. bullous pemphigoid, dermatitis herpetiformis)
- Adrenal insufficiency
- Connective tissue disease (e.g. Churg-Strauss syndrome)
- Interstitial nephritis
- Arsenic, gold toxicity
Evaluation
- CBC with differential
Management
- Directed at underlying cause