Adenosine: Difference between revisions
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== Adult Dosing == | ==General== | ||
*Type: [[Antiarrhythmics]] | |||
*Dosage Forms: | |||
*Common Trade Names: | |||
==Adult Dosing== | |||
*6mg rapid IV bolus over 1-2s | *6mg rapid IV bolus over 1-2s | ||
**If ineffective can try 12mg 2min later | **If ineffective can try 12mg 2min later | ||
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**Lower dose (1st 3mg, 2nd/3rd 6mg) in pt taking carbamazepine (Tegretol), diazepam (Valium) or dipyridamole (Persantine) OR with a heart transplant. | **Lower dose (1st 3mg, 2nd/3rd 6mg) in pt taking carbamazepine (Tegretol), diazepam (Valium) or dipyridamole (Persantine) OR with a heart transplant. | ||
== Contraindications == | === Indications === | ||
*Conversion of reentrant PSVT to NSR | |||
==Pediatric Dosing== | |||
==Special Populations== | |||
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: | |||
*Lactation: | |||
*Renal Dosing | |||
**Adult | |||
**Pediatric | |||
*Hepatic Dosing | |||
**Adult | |||
**Pediatric | |||
==Contraindications== | |||
*Allergy to class/drug | |||
*2nd, 3rd AV block | *2nd, 3rd AV block | ||
*Sick sinus syndrome | *Sick sinus syndrome | ||
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*No effect on anterograde WPW | *No effect on anterograde WPW | ||
==Adverse Reactions== | |||
== Adverse | |||
*Bronchoconstriction (responds to bronchodilators) | *Bronchoconstriction (responds to bronchodilators) | ||
*Bradyarrhythmia | *Bradyarrhythmia | ||
*Hypotension (if given too slowly) | *Hypotension (if given too slowly) | ||
== | ==Pharmacology== | ||
Onset of action = 20-30s Duration of action = 60-90s | *Kinetics: Onset of action = 20-30s Duration of action = 60-90s | ||
*Half-life: | |||
*Metabolism: | |||
*Excretion: | |||
=== Mechanism of Action === | |||
*Negative inotropic, dromotropic, chronotropic effects | |||
*Transient AV nodal block | |||
==See Also== | ==See Also== | ||
==Sources== | |||
<references/> | |||
[[Category:Drugs]] | [[Category:Drugs]] | ||
Revision as of 05:10, 25 February 2015
General
- Type: Antiarrhythmics
- Dosage Forms:
- Common Trade Names:
Adult Dosing
- 6mg rapid IV bolus over 1-2s
- If ineffective can try 12mg 2min later
- If still ineffective can try another 12mg
- If ineffective can try 12mg 2min later
- Caveat
- Higher dose (1st 12mg, 2nd/3rd 18mg) in pt taking methylxanthines (ie caffeine, theophylline)
- Blocks adenosine binding at receptor sites (competitive antagonist)
- Lower dose (1st 3mg, 2nd/3rd 6mg) in pt taking carbamazepine (Tegretol), diazepam (Valium) or dipyridamole (Persantine) OR with a heart transplant.
- Higher dose (1st 12mg, 2nd/3rd 18mg) in pt taking methylxanthines (ie caffeine, theophylline)
Indications
- Conversion of reentrant PSVT to NSR
Pediatric Dosing
Special Populations
- Pregnancy Rating:
- Lactation:
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
- 2nd, 3rd AV block
- Sick sinus syndrome
- Reentrant SVTs not involving AV node are not terminated
- No effect on anterograde WPW
Adverse Reactions
- Bronchoconstriction (responds to bronchodilators)
- Bradyarrhythmia
- Hypotension (if given too slowly)
Pharmacology
- Kinetics: Onset of action = 20-30s Duration of action = 60-90s
- Half-life:
- Metabolism:
- Excretion:
Mechanism of Action
- Negative inotropic, dromotropic, chronotropic effects
- Transient AV nodal block