Aluminum toxicity: Difference between revisions
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*Physical irritant, nuisance particulate | *Physical irritant, nuisance particulate | ||
==Systemic aluminum toxicity | ==Systemic aluminum toxicity== | ||
*Usually in renal patients on long-term dialysis with aluminum-containing dialysate | *Usually in renal patients on long-term dialysis with aluminum-containing dialysate | ||
*Rarely acute | *Rarely acute | ||
Revision as of 21:22, 8 March 2021
Aluminum Metal
- Dusts cause respiratory tract and eye irritation
- Acute exposures can cause bronchoconstriction and asthma-like response
- Chronic exposure can lead to pulmonary fibrosis
- Increased incidence of cancer
Aluminum phosphide
- Used as a fumigant
- Contact with moisture produces phosphine gas
- Respiratory tract irritant
Aluminum oxide
- Physical irritant, nuisance particulate
Systemic aluminum toxicity
- Usually in renal patients on long-term dialysis with aluminum-containing dialysate
- Rarely acute
- Muscle weakness (especially proximal)
- Premature osteoporosis, bone pain, multiple fractures
- Seziures
- Acute or subacute altered mental status
Evaluation
- Aluminum level > 50 µg/L (mcg/dL) suggests aluminum overload and possible toxicity
- Symptomatic patients with levels 20-50 may also need treatment
Management
- Stop exposure
- Chelation with deferoxamine for severe or symptomatic systemic toxicity