Fresh frozen plasma: Difference between revisions
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*Dosage Forms: | *Dosage Forms: | ||
*Common Trade Names: | *Common Trade Names: | ||
==Indications== | |||
*Rapid [[warfarin reversal|reversal of warfarin]] anticoagulation (in setting of bleeding or need for invasive procedure) | |||
*[[hemorrhage|Bleeding]] and multiple [[coagulopathy|coagulation defects]] (e.g. [[DIC]] with significant PT/PTT elevation) | |||
*Correction of coagulation defects for which no specific factor is available | |||
*[[Transfusion]] of more than one blood volume with evidence of active bleeding + coagulopathy | |||
==Adult Dosing== | ==Adult Dosing== | ||
*1 bag = 1 unit = 250 mL | |||
*10-20 mL/kg (4-6 units in 70kg adult) will increase factors by ~20-30% | |||
*Transfuse at least 15 mL/kg at a time (4 units in 70-kg adult) | *Transfuse at least 15 mL/kg at a time (4 units in 70-kg adult) | ||
*Must be thawed in 37 degree Celsius water bath for about 45 minutes prior to administration<ref>Westphal RG, Tindle B, Howard PL, Golden EA, Page GA. Rapid thawing of fresh frozen plasma. Am J Clin Pathol. 1982;78(2):220-222. doi:10.1093/ajcp/78.2.220</ref> | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
*Neonates/small children: 10-20 mL/kg will increase factor levels by 15-25% | |||
==Special Populations== | ==Special Populations== | ||
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: | *[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C | ||
*Lactation: | *Lactation: | ||
*Renal Dosing | *Renal Dosing: | ||
*Hepatic Dosing: | |||
*Hepatic Dosing | |||
==Contraindications== | ==Contraindications== | ||
*Allergy to class/drug | *Allergy to class/drug | ||
*ABO incompatibility | |||
==Adverse Reactions== | ==Adverse Reactions== | ||
===Serious=== | ===Serious=== | ||
*[[Transfusion reactions]] | |||
**[[Intravascular hemolytic transfusion reaction|Hemolytic transfusion reactions]] | |||
**[[Febrile nonhemolytic transfusion reaction]] | |||
**[[Transfusion-associated circulatory overload]] (TACO) | |||
**[[Transfusion-related acute lung injury]] (TRALI) | |||
**[[Transfusion-associated graft-versus-host disease]] | |||
*[[Anaphylaxis]] | |||
*[[Sepsis]] | |||
===Common=== | ===Common=== | ||
*Headache, paresthesia | |||
*Nausea | |||
*Pruritus, urticaria | |||
==Pharmacology== | ==Pharmacology== | ||
| Line 43: | Line 54: | ||
**40 mL/kg raises any factor by 100% (each unit is ~200mL) | **40 mL/kg raises any factor by 100% (each unit is ~200mL) | ||
*May cause fluid overload | *May cause fluid overload | ||
*ABO | *ABO compatibility a must but crossmatch before transfusing not | ||
*INR of FFP is ~1.6; therefore transfusing for INR | *INR of FFP is ~1.6; therefore transfusing for INR <1.7 is not advised<ref>Holland LL and Brooks JP. Toward rational fresh frozen plasma transfusion: The effect of plasma transfusion on coagulation test results. Am J Clin Pathol. 2006;126(1):133-9. </ref> | ||
*Retains active coagulation factors for up to 5 days after being thawed | *Retains active coagulation factors for up to 5 days after being thawed | ||
==See Also== | ==See Also== | ||
*[[Transfusions]] | *[[Transfusions]] | ||
*[[PCC]] | |||
==References== | ==References== | ||
<references/> | <references/> | ||
[[Category: | [[Category:Pharmacology]] | ||
[[Category:Heme/Onc]] | [[Category:Heme/Onc]] | ||
Latest revision as of 14:07, 25 February 2021
General
- Type: Blood products
- Dosage Forms:
- Common Trade Names:
Indications
- Rapid reversal of warfarin anticoagulation (in setting of bleeding or need for invasive procedure)
- Bleeding and multiple coagulation defects (e.g. DIC with significant PT/PTT elevation)
- Correction of coagulation defects for which no specific factor is available
- Transfusion of more than one blood volume with evidence of active bleeding + coagulopathy
Adult Dosing
- 1 bag = 1 unit = 250 mL
- 10-20 mL/kg (4-6 units in 70kg adult) will increase factors by ~20-30%
- Transfuse at least 15 mL/kg at a time (4 units in 70-kg adult)
- Must be thawed in 37 degree Celsius water bath for about 45 minutes prior to administration[1]
Pediatric Dosing
- Neonates/small children: 10-20 mL/kg will increase factor levels by 15-25%
Special Populations
- Pregnancy Rating: C
- Lactation:
- Renal Dosing:
- Hepatic Dosing:
Contraindications
- Allergy to class/drug
- ABO incompatibility
Adverse Reactions
Serious
Common
- Headache, paresthesia
- Nausea
- Pruritus, urticaria
Pharmacology
- Half-life:
- Metabolism:
- Excretion:
- Mechanism of Action:
Comments
- Contains all coagulation factors and fibrinogen
- 40 mL/kg raises any factor by 100% (each unit is ~200mL)
- May cause fluid overload
- ABO compatibility a must but crossmatch before transfusing not
- INR of FFP is ~1.6; therefore transfusing for INR <1.7 is not advised[2]
- Retains active coagulation factors for up to 5 days after being thawed
See Also
References
- ↑ Westphal RG, Tindle B, Howard PL, Golden EA, Page GA. Rapid thawing of fresh frozen plasma. Am J Clin Pathol. 1982;78(2):220-222. doi:10.1093/ajcp/78.2.220
- ↑ Holland LL and Brooks JP. Toward rational fresh frozen plasma transfusion: The effect of plasma transfusion on coagulation test results. Am J Clin Pathol. 2006;126(1):133-9.