Benztropine: Difference between revisions
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*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: B | *[[Drug Ratings in Pregnancy|Pregnancy Rating]]: B | ||
*[[Lactation risk categories|Lactation risk]]: Infant risk cannot be ruled out | *[[Lactation risk categories|Lactation risk]]: Infant risk cannot be ruled out | ||
Renal: no adjustment | *Renal: no adjustment | ||
Hepatic: no adjustment | *Hepatic: no adjustment | ||
==Contraindications== | ==Contraindications== | ||
| Line 42: | Line 42: | ||
==See Also== | ==See Also== | ||
*[[Extrapyramidal reaction]] | *[[Extrapyramidal reaction]] | ||
*[[Dystonic reaction]] | |||
*[[Antipsychotics]] | *[[Antipsychotics]] | ||
*[[Anticholinergics]] | *[[Anticholinergics]] | ||
==References== | ==References== | ||
*2019 American Geriatrics Society Beers Criteria Update Expert Panel. American Geriatrics Society 2019 updated AGS Beers Criteria for Potentially Inappropriate Medication Use in Older Adults. J Am Geriatr Soc. 2019;67(4):674-694. doi: 10.1111/jgs.15767. [PubMed 30693946] | |||
*Bellman MH. Treatment of phenothiazine drug intoxication with benztropine. Arch Dis Child.1974;49(8):664-665. [PubMed 4424791] | |||
*Benztropine tablets [prescribing information]. Livonia, MI: Major Pharmaceuticals; October 2017. | |||
*Brocks DR. Anticholinergic drugs used in Parkinson's disease: An overlooked class of drugs from a pharmacokinetic perspective. J Pharm Pharm Sci. 1999;2(2):39-46. [PubMed 10952768] | |||
*Cogentin (benztropine) injection [prescribing information]. Lake Forest, IL: Akorn Inc; May 2013. | |||
*Duncan MA, Nikolov NM, and O’Kelly B, “Acute Chorea Due to Ondansetron in an Obstetric Patient,” Int J Obstet Anesth, 2001, 10(4):309-11. [PubMed 15321589] | |||
*Falterman CG, Richardson CJ. Small left colon syndrome associated with maternal ingestion of psychotropic drugs. J Pediatr. 1980;97(2):308-310. [PubMed 740090] | |||
*Habre W, Wilson D, Johnson CM. Extrapyramidal side-effects from droperidol mixed with morphine for patient-controlled analgesia in two children. Paediatr Anaesth. 1999;9(4):362-364. [PubMed 10411778] | |||
*Joseph MM, King WD. Dystonic reaction following recommended use of a cold syrup. Ann Emerg Med. 1995;26(6):749-751. [PubMed 7492048] | |||
*Kreyenbuhl J, Buchanan RW, Dickerson FB, Dixon LB; Schizophrenia Patient Outcomes Research Team (PORT). The Schizophrenia Patient Outcomes Research Team (PORT): updated treatment recommendations 2009. Schizophr Bull. 2010;36(1):94-103. doi: 10.1093/schbul/sbp130. [PubMed 19955388] | |||
<references/> | <references/> | ||
[[Category:Pharmacology]] | [[Category:Pharmacology]] | ||
Latest revision as of 03:02, 24 February 2021
Administration
- Type: Anticholinergic
- Dosage Forms: tablet, injectable solution
- Dosage Strengths: tablet: 0.5, 1, 2mg; injectable solution: 1mg/mL
- Routes of Administration: IV, IM, oral
- Common Trade Names: Cogentin
Adult Dosing
- Extrapyramidal disease: 1-4 mg IV/IM/PO 1-2 times daily
- Parkinsonism: 0.5 mg IM/IV/PO daily, titrate up in 0.5mg increments
Pediatric Dosing
- Contraindicated children <3 years old. Otherwise, same as adult dosing
Special Populations
- Pregnancy Rating: B
- Lactation risk: Infant risk cannot be ruled out
- Renal: no adjustment
- Hepatic: no adjustment
Contraindications
- Allergy to class/drug
- Age <3 years
Adverse Reactions
Serious
- Psychosis, confusion, hallucinations
- Hyperpyrexia, heat stroke, anhidrosis
- Paralytic ileus
Common
- Tachycardia
- Constipation, nausea, xerostomia
- Blurry vision
- Urinary retention
Pharmacology
- Half-life: duration of action is around 24 hours
- Metabolism:
- Excretion:
Mechanism of Action
- Anticholinergic, reduces imbalance between acetylcholine and dopamine
Comments
See Also
References
- 2019 American Geriatrics Society Beers Criteria Update Expert Panel. American Geriatrics Society 2019 updated AGS Beers Criteria for Potentially Inappropriate Medication Use in Older Adults. J Am Geriatr Soc. 2019;67(4):674-694. doi: 10.1111/jgs.15767. [PubMed 30693946]
- Bellman MH. Treatment of phenothiazine drug intoxication with benztropine. Arch Dis Child.1974;49(8):664-665. [PubMed 4424791]
- Benztropine tablets [prescribing information]. Livonia, MI: Major Pharmaceuticals; October 2017.
- Brocks DR. Anticholinergic drugs used in Parkinson's disease: An overlooked class of drugs from a pharmacokinetic perspective. J Pharm Pharm Sci. 1999;2(2):39-46. [PubMed 10952768]
- Cogentin (benztropine) injection [prescribing information]. Lake Forest, IL: Akorn Inc; May 2013.
- Duncan MA, Nikolov NM, and O’Kelly B, “Acute Chorea Due to Ondansetron in an Obstetric Patient,” Int J Obstet Anesth, 2001, 10(4):309-11. [PubMed 15321589]
- Falterman CG, Richardson CJ. Small left colon syndrome associated with maternal ingestion of psychotropic drugs. J Pediatr. 1980;97(2):308-310. [PubMed 740090]
- Habre W, Wilson D, Johnson CM. Extrapyramidal side-effects from droperidol mixed with morphine for patient-controlled analgesia in two children. Paediatr Anaesth. 1999;9(4):362-364. [PubMed 10411778]
- Joseph MM, King WD. Dystonic reaction following recommended use of a cold syrup. Ann Emerg Med. 1995;26(6):749-751. [PubMed 7492048]
- Kreyenbuhl J, Buchanan RW, Dickerson FB, Dixon LB; Schizophrenia Patient Outcomes Research Team (PORT). The Schizophrenia Patient Outcomes Research Team (PORT): updated treatment recommendations 2009. Schizophr Bull. 2010;36(1):94-103. doi: 10.1093/schbul/sbp130. [PubMed 19955388]