Rifaximin

Administration

• Type: Antibiotic
• Dosage Forms: 200, 550
• Routes of Administration: Oral
• Common Trade Names: Xifaxan

Adult Dosing

• Traveler's diarrhea, E. coli-induced: 200mg PO tid x3 days

• Hepatic encephalopathy: 550mg PO bid

• IBS, diarrhea-predominant: 550mg PO tid x14 days
  • May repeat dose up to 2x if recurrent disease

Pediatric Dosing

For > 12 yrs old

• Traveler's diarrhea, E. coli-induced: 200mg PO tid x3 days

Special Populations

• Pregnancy Rating: C
• Lactation risk: Infant risk cannot be ruled out

Renal Dosing

• No adjustment

Hepatic Dosing

• No adjustment

Contraindications

• Allergy to class/drug
• caution if hepatic impairment (Child-Pugh Class C)
• caution if recent antibiotic-associated colitis

Adverse Reactions

Serious

• superinfection
• C. difficile-assoc. diarrhea
• hypersensitivity reaction
• angioedema
• anaphylaxis
• exfoliative dermatitis

Common

• peripheral edema
• nausea
• dizziness
• fatigue

References

<Epocrates, UpToDate>