Ethambutol: Difference between revisions
ClaireLewis (talk | contribs) (Created page with "==Administration== *Type: Antibiotic, anti-TB *Dosage Forms: *Routes of Administration: Oral *Common Trade Names: ==Adult Dosing== *15-25 mg/kg PO daily (in combination...") |
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*Renal dosing: | *Renal dosing: | ||
**Adjust dose/frequency based on serum drug levels if CrCl <79mL/min | **Adjust dose/frequency based on serum drug levels if CrCl <79mL/min | ||
**CrCl <10: 15-25mg/kg q48h OR 3 times per week | **CrCl <10: 15-25mg/kg q48h '''OR''' 3 times per week | ||
**CrCl 10-15: 10-25mg/kg q24-36h | **CrCl 10-15: 10-25mg/kg q24-36h | ||
**Hemodialysis: 15-25mg/kg 3 times per week after HD | **Hemodialysis: 15-25mg/kg 3 times per week after HD | ||
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*Hepatotoxicity | *Hepatotoxicity | ||
===Common=== | ===Common=== | ||
* nausea/vomiting/diarrhea | |||
* anorexia | |||
* headache | |||
* headache | |||
* malaise | |||
* LFT elevation | |||
==Pharmacology== | ==Pharmacology== | ||
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[[Category:Pharmacology]] | [[Category:Pharmacology]] | ||
[[Category:ID]] | |||
Latest revision as of 19:35, 22 September 2019
Administration
- Type: Antibiotic, anti-TB
- Dosage Forms:
- Routes of Administration: Oral
- Common Trade Names:
Adult Dosing
- 15-25 mg/kg PO daily (in combination with other agents)
Pediatric Dosing
- 15-25mg/kg PO daily
Special Populations
- Pregnancy Rating: C
- Lactation risk: Infant risk is minimal
- Renal dosing:
- Adjust dose/frequency based on serum drug levels if CrCl <79mL/min
- CrCl <10: 15-25mg/kg q48h OR 3 times per week
- CrCl 10-15: 10-25mg/kg q24-36h
- Hemodialysis: 15-25mg/kg 3 times per week after HD
- Hepatic dosing:
Contraindications
- Allergy to class/drug
- Inability to appreciate or report visual side effects (e.g. infants, comatose)
Adverse Reactions
Serious
- Optic neuritis
- Hepatotoxicity
Common
- nausea/vomiting/diarrhea
- anorexia
- headache
- headache
- malaise
- LFT elevation
Pharmacology
- Half-life: 2.5-4h
- Metabolism: Liver
- Excretion: Renal, fecal
Mechanism of Action
- Inhibits mycobacteria synthesis of metabolites, thus impairing cell metabolism/multiplication