Cyproheptadine: Difference between revisions
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==Administration== | ==Administration== | ||
*Dosage Forms: | *Dosage Forms: 4mg tab, 2mg/5ml solution | ||
*Routes of Administration: oral | *Routes of Administration: oral | ||
*Common Trade Names: Periactin or Peritol | *Common Trade Names: Periactin or Peritol | ||
==Adult Dosing== | ==Adult Dosing== | ||
* initial dose of | *initial dose of 12mg is recommended, followed by 2mg every two hours until clinical response is seen | ||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
*Children younger than two years can be given approximately 0. | *Children younger than two years can be given approximately 0.06mg/kg per dose every six hours, if needed (not to exceed 0.25mg/kg/day). | ||
*Children two to six years can be given | *Children two to six years can be given 2mg every six hours, if needed (not to exceed 12mg/day). | ||
*Children 7 to 14 years can be given | *Children 7 to 14 years can be given 4mg every six hours, if needed (not to exceed 16mg/day). | ||
==Special Populations== | ==Special Populations== | ||
| Line 18: | Line 18: | ||
===Renal Dosing=== | ===Renal Dosing=== | ||
* No recommendations | *No recommendations | ||
===Hepatic Dosing=== | ===Hepatic Dosing=== | ||
* No recommendations | *No recommendations | ||
==Contraindications== | ==Contraindications== | ||
*Allergy to class/drug | *Allergy to class/drug | ||
*Treatment in newborns or nursing mothers | |||
==Adverse Reactions== | ==Adverse Reactions== | ||
===Serious=== | ===Serious=== | ||
* | *Hypotension | ||
===Common=== | ===Common=== | ||
* | *Sedation | ||
==Pharmacology== | |||
* Half-life: 1-4 hours | |||
* Metabolism: Liver | |||
* Excretion: Urine | |||
==Mechanism of Action== | ==Mechanism of Action== | ||
* | *Histamine-1 receptor antagonist | ||
*5-HT1A and 5-HT2A (seritonin) antagonistic properties | |||
*Weak anticholinergic activity | |||
==Comments== | ==Comments== | ||
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*1. Boyer EW. Serotonin syndrome. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. (Accessed on January 11, 2016.) | *1. Boyer EW. Serotonin syndrome. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. (Accessed on January 11, 2016.) | ||
[[Category: | [[Category:Pharmacology]] [[Category:Toxicology]] | ||
Latest revision as of 22:55, 20 September 2019
Uses
- Treatment of serotonin syndrome
Administration
- Dosage Forms: 4mg tab, 2mg/5ml solution
- Routes of Administration: oral
- Common Trade Names: Periactin or Peritol
Adult Dosing
- initial dose of 12mg is recommended, followed by 2mg every two hours until clinical response is seen
Pediatric Dosing
- Children younger than two years can be given approximately 0.06mg/kg per dose every six hours, if needed (not to exceed 0.25mg/kg/day).
- Children two to six years can be given 2mg every six hours, if needed (not to exceed 12mg/day).
- Children 7 to 14 years can be given 4mg every six hours, if needed (not to exceed 16mg/day).
Special Populations
Renal Dosing
- No recommendations
Hepatic Dosing
- No recommendations
Contraindications
- Allergy to class/drug
- Treatment in newborns or nursing mothers
Adverse Reactions
Serious
- Hypotension
Common
- Sedation
Pharmacology
- Half-life: 1-4 hours
- Metabolism: Liver
- Excretion: Urine
Mechanism of Action
- Histamine-1 receptor antagonist
- 5-HT1A and 5-HT2A (seritonin) antagonistic properties
- Weak anticholinergic activity
Comments
See Also
References
- 1. Boyer EW. Serotonin syndrome. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. (Accessed on January 11, 2016.)