Carboprost: Difference between revisions
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==Contraindications== | ==Contraindications== | ||
*Allergy to class/drug | *Allergy to class/drug | ||
* | *Hypersensitivity to [[prostaglandin]] | ||
*[[PID]], acute | *[[PID]], acute | ||
*Acute renal impairment | *Acute [[renal impairment]] | ||
*Acute pulmonary disease | *Acute pulmonary disease | ||
*Acute hepatic disease | *Acute hepatic disease | ||
* | *CAD | ||
*Caution if [[asthma]] | *Caution if [[asthma]] | ||
| Line 44: | Line 44: | ||
*[[Uterine rupture]] | *[[Uterine rupture]] | ||
*[[Hemorrhage]], [[hematemesis]] | *[[Hemorrhage]], [[hematemesis]] | ||
*Respiratory distress, [[pulmonary edema]] | *[[Respiratory distress]], [[pulmonary edema]] | ||
===Common=== | ===Common=== | ||
Revision as of 19:59, 17 September 2019
Administration
- Type: Uterotonic
- Dosage Forms: 250 mcg/mL
- Routes of Administration: IV, IM
- Common Trade Names: Hemabate
Adult Dosing
Postpartum hemorrhage
- 250 mcg IM x1
- May repeat q15-90min for refractory bleeding
- Max 2mg total dose
Pediatric Dosing
- Pediatric dosing not applicable or safety has not been established in pediatric patients.
Special Populations
Pregnancy Rating
- Avoid use in 3rd trimester
- Possible risk of embryo-fetal toxicity
Lactation risk
- Caution advised when breastfeeding
Renal Dosing
- Adult: Contraindicated in acute impairment
- Pediatric: N/a
Hepatic Dosing
- Adult: Contraindicated in acute impairment
- Pediatric: N/a
Contraindications
- Allergy to class/drug
- Hypersensitivity to prostaglandin
- PID, acute
- Acute renal impairment
- Acute pulmonary disease
- Acute hepatic disease
- CAD
- Caution if asthma
Adverse Reactions
Serious
Common
Pharmacology
- Half-life: Unknown
- Metabolism: Liver primarily, lung
- Excretion: Urine (<1% unchanged)
Mechanism of Action
- Stimulates smooth muscle and uterine contractions
- Acts as synthetic prostaglandin