Streptococcus pneumoniae: Difference between revisions
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*Isolation of this organism is always significant and should be treated<ref>Antibiotic Therapy for Positive Blood Cultures. Perez-Jorge EV, et al. Antimicrobe. http://www.antimicrobe.org/new/e38rev2.asp</ref>
*Isolation of this organism is always significant and should be treated<ref>Antibiotic Therapy for Positive Blood Cultures. Perez-Jorge EV, et al. Antimicrobe. http://www.antimicrobe.org/new/e38rev2.asp</ref>


==[[Antibiotic Sensitivities]]<ref>Sanford Guide to Antimicrobial Therapy 2010</ref>==
==[[Antibiotic Sensitivities]]<ref>Sanford Guide to Antimicrobial Therapy 2014</ref>==
{| class="wikitable"
{| class="wikitable"
| align="center" style="background:#f0f0f0;"|'''Organisms'''
| align="center" style="background:#f0f0f0;"|'''Category'''
| align="center" style="background:#f0f0f0;"|''''''
| align="center" style="background:#f0f0f0;"|'''Antibiotic'''
| align="center" style="background:#f0f0f0;"|'''Strep. pneumoniae'''
| align="center" style="background:#f0f0f0;"|'''[[Strep. Pneumoniae]]'''
|-
|-
| Penicillins||Penicillin G||+
| [[Penicillins]]||[[Penicillin G]]||S
|-
|-
| ||Penicillin V||+
| ||[[Penicillin V]]||S
|-
|-
| Anti-Staphylocccal Penicillins||Methicillin||+
| ||[[Methicillin]]||S
|-
|-
| ||Nafcillin/Oxacillin||+
| ||[[Nafcillin]]/[[Oxacillin]]||S
|-
|-
| ||Cloxacillin/Diclox.||+
| ||[[Cloxacillin]]/[[Diclox.]]||S
|-
|-
| Amino-Penicillins||AMP/Amox||+
| Amino-[[Penicillins]]||[[AMP]]/[[Amox]]||S
|-
|-
| ||Amox/Clav||+
| ||[[Amox-Clav]]||S
|-
|-
| ||AMP-Sulb||+
| ||[[AMP-Sulb]]||S
|-
|-
| Anti-Pseudomonal Penicillins||Ticarcillin||+
| Anti-Pseudomonal [[Penicillins]]||[[Ticarcillin]]||S
|-
|-
| ||Ticar-Clav||+
| ||[[Ticar-Clav]]||S
|-
|-
| ||Pip-Taxo||+
| ||[[Pip-Tazo]]||S
|-
|-
| [[Carbapenems]]||Piperacillin||+
| ||Piperacillin||S
|-
|-
| ||Doripenem||+
| [[Carbapenems]]||Doripenem||S
|-
|-
| ||Ertapenem||+
| ||[[Ertapenem]]||S
|-
|-
| ||Imipenem||+
| ||[[Imipenem]]||S
|-
|-
| ||Meropenem||+
| ||[[Meropenem]]||S
|-
|-
| ||[[Aztreonam]]||0
| ||[[Aztreonam]]||R
|-
|-
| [[Fluroquinolones]]||[[Ciprofloxacin]]||+/-
| [[Fluroquinolones]]||[[Ciprofloxacin]]||I
|-
|-
| ||Ofloxacin||+/-
| ||[[Ofloxacin]]||I
|-
|-
| ||Pefloxacin||0
| ||Pefloxacin||R
|-
|-
| ||[[Levofloxacin]]||+
| ||[[Levofloxacin]]||S
|-
|-
| ||Moxifloxacin||+
| ||[[Moxifloxacin]]||S
|-
|-
| ||Gemifloxacin||+
| ||Gemifloxacin||S
|-
|-
| ||Gatifloxacin||+
| ||Gatifloxacin||S
|-
|-
| 1st G [[Cephalosporin]]||Cefazolin||+
| 1st G [[Cephalo]]||Cefazolin||S
|-
|-
| 2nd G. [[Cephalosporin]]||[[Cefotetan]]||+
| 2nd G. [[Cephalo]]||[[Cefotetan]]||S
|-
|-
| ||Cefoxitin||+
| ||[[Cefoxitin]]||S
|-
|-
| ||Cefuroxime||+
| ||[[Cefuroxime]]||S
|-
|-
| 3rd/4th G. [[Cephalosporin]]||[[CefoTAXime]]||+
| 3rd/4th G. [[Cephalo]]||[[Cefotaxime]]||S
|-
|-
| ||Cefizoxime||+
| ||Cefizoxime||S
|-
|-
| ||[[CefTRIAXone]]||+
| ||[[CefTRIAXone]]||S
|-
|-
| ||Ceftobiprole||+
| ||Ceftaroline||S
|-
|-
| ||Ceftaroline||+
| ||[[CefTAZidime]]||S
|-
|-
| ||[[CefTAZidime]]||+
| ||[[Cefepime]]||S
|-
|-
| ||[[Cefepime]]||+
| Oral 1st G. [[Cephalo]]||Cefadroxil||S
|-
|-
| Oral 1st G.  [[Cephalosporin]]||Cefadroxil||+
| ||[[Cephalexin]]||S
|-
|-
| ||[[Cephalexin]]||+
| Oral 2nd G. [[Cephalo]]||Cefaclor/Loracarbef||S
|-
|-
| Oral 2nd G.  [[Cephalosporin]]||Cefaclor/Loracarbef||+
| ||Cefproxil||S
|-
|-
| ||Cefproxil||+
| ||Cefuroxime axetil||S
|-
|-
| ||Cefuroxime axetil||+
| Oral 3rd G. [[Cephalo]]||Cefixime||S
|-
|-
| Oral 3rd G.  [[Cephalosporin]]||Cefixime||+
| ||Ceftibuten||I
|-
|-
| ||Ceftibuten||+/-
| ||Cefpodox/Cefdinir/Cefditoren||S
|-
|-
| ||Cefpodox/Cefdinir/Cefditoren||+
| [[Aminoglycosides]]||[[Gentamicin]]||R
|-
|-
| [[Aminoglycosides]]||[[Gentamicin]]||0
| ||Tobramycin||R
|-
|-
| ||Tobramycin||0
| ||[[Amikacin]]||R
|-
|-
| ||[[Amikacin]]||0
| ||[[Chloramphenicol]]||S
|-
|-
| ||Chloramphenicol||+
| ||[[Clindamycin]]||S
|-
|-
| ||[[Clindamycin]]||+
| [[Macrolides]]||Erythromycin||I
|-
|-
| [[Macrolides]]||Erythromycin||+
| ||[[Azithromycin]]||I
|-
|-
| ||[[Azithromycin]]||+
| ||Clarithromycin||I
|-
|-
| ||Clarithromycin||+
| Ketolide||Telithromycin||S
|-
|-
| Ketolide||Telithromycin||+/-
| Tetracyclines||[[Doxycycline]]||S
|-
|-
| Tetracyclines||[[Doxycycline]]||+
| ||Minocycline||S
|-
|-
| ||Minocycline||+
| Glycylcycline||Tigecycline||S
|-
|-
| Glycylcycline||Tigecycline||+
| ||Daptomycin||X4
|-
|-
| Glyco/Lipoclycopeptides||[[Vancomycin]]||+
| Glyco/Lipoclycopeptides||[[Vancomycin]]||S
|-
|-
| ||Teicoplanin||+
| ||Teicoplanin||S
|-
|-
| ||Telavancin||+
| ||Telavancin||S
|-
|-
| ||Fusidic Acid||+/-
| ||Fusidic Acid||I
|-
|-
| ||Trimethoprim||+/-
| ||Trimethoprim||I
|-
|-
| ||[[TMP-SMX]]||+
| ||[[TMP-SMX]]||S
|-
|-
| Urinary Agents||[[Nitrofurantoin]]||+
| Urinary Agents||[[Nitrofurantoin]]||S
|-
|-
| ||Fosfomycin||
| ||Fosfomycin||S
|-
|-
| Other||[[Rifampin]]||+
| Other||[[Rifampin]]||S
|-
|-
| ||[[Metronidazole]]||0
| ||[[Metronidazole]]||R
|-
|-
| ||Quinupristin dalfoppristin||+
| ||Quinupristin dalfoppristin||S
|-
|-
| ||Linezolid||+
| ||[[Linezolid]]||S
|-
|-
| ||[[Daptomycin]]||+
| ||Colistimethate||R
|-
| ||Colistimethate||0
|}
|}
===Key===
===Key===
{{Template:Antibacterial Spectra Key}}
{{Template:Antibacterial Spectra Key}}

Revision as of 06:28, 3 June 2014

Background

Antibiotic Sensitivities[2]

Category Antibiotic Strep. Pneumoniae
Penicillins Penicillin G S
Penicillin V S
Methicillin S
Nafcillin/Oxacillin S
Cloxacillin/Diclox. S
Amino-Penicillins AMP/Amox S
Amox-Clav S
AMP-Sulb S
Anti-Pseudomonal Penicillins Ticarcillin S
Ticar-Clav S
Pip-Tazo S
Piperacillin S
Carbapenems Doripenem S
Ertapenem S
Imipenem S
Meropenem S
Aztreonam R
Fluroquinolones Ciprofloxacin I
Ofloxacin I
Pefloxacin R
Levofloxacin S
Moxifloxacin S
Gemifloxacin S
Gatifloxacin S
1st G Cephalo Cefazolin S
2nd G. Cephalo Cefotetan S
Cefoxitin S
Cefuroxime S
3rd/4th G. Cephalo Cefotaxime S
Cefizoxime S
CefTRIAXone S
Ceftaroline S
CefTAZidime S
Cefepime S
Oral 1st G. Cephalo Cefadroxil S
Cephalexin S
Oral 2nd G. Cephalo Cefaclor/Loracarbef S
Cefproxil S
Cefuroxime axetil S
Oral 3rd G. Cephalo Cefixime S
Ceftibuten I
Cefpodox/Cefdinir/Cefditoren S
Aminoglycosides Gentamicin R
Tobramycin R
Amikacin R
Chloramphenicol S
Clindamycin S
Macrolides Erythromycin I
Azithromycin I
Clarithromycin I
Ketolide Telithromycin S
Tetracyclines Doxycycline S
Minocycline S
Glycylcycline Tigecycline S
Daptomycin X4
Glyco/Lipoclycopeptides Vancomycin S
Teicoplanin S
Telavancin S
Fusidic Acid I
Trimethoprim I
TMP-SMX S
Urinary Agents Nitrofurantoin S
Fosfomycin S
Other Rifampin S
Metronidazole R
Quinupristin dalfoppristin S
Linezolid S
Colistimethate R

Key

  • S susceptible/sensitive (usually)
  • I intermediate (variably susceptible/resistant)
  • R resistant (or not effective clinically)
  • S+ synergistic with cell wall antibiotics
  • U sensitive for UTI only (non systemic infection)
  • X1 no data
  • X2 active in vitro, but not used clinically
  • X3 active in vitro, but not clinically effective for Group A strep pharyngitis or infections due to E. faecalis
  • X4 active in vitro, but not clinically effective for strep pneumonia

Table Overview

Gram Positives
Cocci
Clusters
Pairs/Chains
Other
Rods
Gram Negatives
Cocci
Rods
Lactose Fermenters
Lactose Non-Fermenters
Other
Rods/Cocci
Anaerobes

See Also

References

  1. ↑ Antibiotic Therapy for Positive Blood Cultures. Perez-Jorge EV, et al. Antimicrobe. http://www.antimicrobe.org/new/e38rev2.asp
  2. ↑ Sanford Guide to Antimicrobial Therapy 2014
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