Cefepime: Difference between revisions
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==Adult Dosing== | ==Adult Dosing== | ||
'''<big>Bacterial Infections</big>''' | |||
* 1-2 g IV q12H (Max: 6 g/24h; dose, duration varies with infection type, severity) | |||
'''<big>Febrile Neutropenia</big>''' | |||
* 2g IV q8H | |||
<big>'''UTI, mild-moderate'''</big> | |||
* 0.5-1g IV/IM q12H x7-10 days (IM only for UTI due to E. coli) | |||
<big>'''UTI, severe'''</big> | |||
* 2g IV q12H x10 days | |||
<big>'''Renal dosing'''</big> | |||
* Febrile Neutropenia: CrCl 30-60: 2 g q12H; CrCl 11-29: 2 g q24H; CrCL <11: 2gx1, then 1g q24H; HD: 1g q24H, give after dialysis; PD: 2g q48H | |||
*All other infections: CrCl 30-60: give q24h; CrCl 11-29: give usual dose x1, then 0.5-1 g q24h; CrCl <11: give usual dose x1, then 250-500 mg q24h; HD: 1 g x1, then 500 mg q24h, give after dialysis; PD: give usual dose q48h | |||
<big>'''Hepatic Doseing'''</big> | |||
* no adjustment | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
Revision as of 00:06, 17 May 2014
General
- Type: Fourth generation cephalosporin
- Dosage Forms: IV, IM
- Common Trade Names: Maxipime
Adult Dosing
Bacterial Infections
- 1-2 g IV q12H (Max: 6 g/24h; dose, duration varies with infection type, severity)
Febrile Neutropenia
- 2g IV q8H
UTI, mild-moderate
- 0.5-1g IV/IM q12H x7-10 days (IM only for UTI due to E. coli)
UTI, severe
- 2g IV q12H x10 days
Renal dosing
- Febrile Neutropenia: CrCl 30-60: 2 g q12H; CrCl 11-29: 2 g q24H; CrCL <11: 2gx1, then 1g q24H; HD: 1g q24H, give after dialysis; PD: 2g q48H
- All other infections: CrCl 30-60: give q24h; CrCl 11-29: give usual dose x1, then 0.5-1 g q24h; CrCl <11: give usual dose x1, then 250-500 mg q24h; HD: 1 g x1, then 500 mg q24h, give after dialysis; PD: give usual dose q48h
Hepatic Doseing
- no adjustment
Pediatric Dosing
Special Populations
- Pregnancy:
- Lactation:
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
Common
Pharmacology
- Half-life:
- Metabolism:
- Excretion:
- Mechanism of Action: