Ciprofloxacin

General

• Type: Fluoroquinolones
• Dosage Forms: IV; PO (Standard: 100, 250, 500; ER 500, 1000)
• Common Trade Names: Cipro

Adult Dosing

General

• PO
  • 250-750mg PO q12h
  • First Dose: 250-750mg PO x1
• IV
  • 200-400mg IV q12
  • First Dose: 400mg IV x 1
  • Alt: 400mg IV q8h

UTI

• Uncomplicated
  • 500mg ER PO q24h x 3 days
  • Alt: 250mg PO q12h x 3 days
• Complicated
  • IV: 400mg IV q12h x 7-14 days
  • PO: 1000mg ER PO q24h x 7-14 days
    • Alt: 500mg PO q12h x 7-14 days

Anthrax

• Inhalational, Gi, oropharyngeal
  • 400mg IV q12h OR 500mg PO q12 x 60 days
  • First dose: 400mg IV + 1-2 additional antibiotics
• Cutaneous
  • 400mg IV q12h OR 500mg PO q12 x 7-10 days
    • Info: Give x 60 days if bioterrorism suspected
• Post-Exposure Prophylaxis
  • 500mg PO q12h x 60 days (or exposure excluded)

Typhoid Fever

• 500mg PO q12h x 2 weeks

Chancroid

• 500mg PO q12h x 3 days

Salmonella

• Acute
  • 500-750mg PO q12h x 3-7 days
    • Extend treatment x 1 week if immunocompromised
• Chronic Carrier
  • 750mg PO q12h x 1 month

Pediatric Dosing

General

• PO
  • 20-30 mg/kg/day PO divided q12h
  • First Dose: 10-15 mg/kg PO x 1
  • Max: 750 mg/dose PO
• IV
  • 15-30 mg/kg/day IV divided q8-12h
  • First Dose: 5-15 mg/kg IV x 1
  • Max: 400 mg/dose IV

Anthrax

Max (All): 400mg/dose IV or 500mg/dose PO

• Inhalational, GI, Oropharyngeal
  • 20-30 mg/kg/day IV/PO divided q12h x 60 days
  • First Dose: 10-15 mg/kg IV x 1 (give with 1-2 additional antibiotics)
• Cutaneous
  • 20-30 mg/kg/day IV/PO divided q12h x 7-10 days
  • First Dose: 10-15 mg/kg IV/PO x 1
    • Info: Give x 60 days if bioterrorism suspected
• Post-Exposure Prophylaxis
  • 20-30 mg/kg/day PO divided q12h x 60 days (or exposure excluded)
  • First Dose: 10-15 mg/kg PO x 1

UTI, Complicated (1-17 Years Old)

Not first line given adverse effects

• IV
  • 6-10 mg/kg IV q8h
  • First Dose:
  • Max: 400 mg/dose IV
• PO
  • 10-20 mg/kg PO q12h
  • First Dose:
  • Max: 750 mg/dose PO

Special Populations

• Pregnancy: C (but indicated for anthrax)
• Lactation: Probably safe
• Renal Dosing
  • Adult
  • Pediatric
• Hepatic Dosing
  • Adult
  • Pediatric

Contraindications

• Allergy to class/drug

Pharmacology

• Half-life:
• Metabolism:
• Excretion:
• Mechanism of Action:

See Also

• Antibiotics (Main)