Streptococcus pneumoniae: Difference between revisions
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==Background==
==Background==
*[[Gram Positive]] cocci in clusters/pairs


==Antibiotic Sensitivities<ref>Sanford Guide to Antimicrobial Therapy 2010</ref>==
==Antibiotic Sensitivities<ref>Sanford Guide to Antimicrobial Therapy 2010</ref>==
{| class="wikitable"
{| class="wikitable"
 
| align="center" style="background:#f0f0f0;"|'''Organisms'''
| align="center" style="background:#f0f0f0;"|''''''
| align="center" style="background:#f0f0f0;"|'''Strep. pneumoniae'''
|-
| Penicillins||Penicillin G||+
|-
| ||Penicillin V||+
|-
| Anti-Staphylocccal Penicillins||Methicillin||+
|-
| ||Nafcillin/Oxacillin||+
|-
| ||Cloxacillin/Diclox.||+
|-
| Amino-Penicillins||AMP/Amox||+
|-
| ||Amox/Clav||+
|-
| ||AMP-Sulb||+
|-
| Anti-Pseudomonal Penicillins||Ticarcillin||+
|-
| ||Ticar-Clav||+
|-
| ||Pip-Taxo||+
|-
| [[Carbapenems]]||Piperacillin||+
|-
| ||Doripenem||+
|-
| ||Ertapenem||+
|-
| ||Imipenem||+
|-
| ||Meropenem||+
|-
| ||[[Aztreonam]]||0
|-
| [[Fluroquinolones]]||[[Ciprofloxacin]]||+/-
|-
| ||Ofloxacin||+/-
|-
| ||Pefloxacin||0
|-
| ||[[Levofloxacin]]||+
|-
| ||Moxifloxacin||+
|-
| ||Gemifloxacin||+
|-
| ||Gatifloxacin||+
|-
| 1st G [[Cephalosporin]]||Cefazolin||+
|-
| 2nd G.  [[Cephalosporin]]||[[Cefotetan]]||+
|-
| ||Cefoxitin||+
|-
| ||Cefuroxime||+
|-
| 3rd/4th G.  [[Cephalosporin]]||[[CefoTAXime]]||+
|-
| ||Cefizoxime||+
|-
| ||[[CefTRIAXone]]||+
|-
| ||Ceftobiprole||+
|-
| ||Ceftaroline||+
|-
| ||[[CefTAZidime]]||+
|-
| ||[[Cefepime]]||+
|-
| Oral 1st G.  [[Cephalosporin]]||Cefadroxil||+
|-
| ||[[Cephalexin]]||+
|-
| Oral 2nd G.  [[Cephalosporin]]||Cefaclor/Loracarbef||+
|-
| ||Cefproxil||+
|-
| ||Cefuroxime axetil||+
|-
| Oral 3rd G.  [[Cephalosporin]]||Cefixime||+
|-
| ||Ceftibuten||+/-
|-
| ||Cefpodox/Cefdinir/Cefditoren||+
|-
| [[Aminoglycosides]]||[[Gentamicin]]||0
|-
| ||Tobramycin||0
|-
| ||[[Amikacin]]||0
|-
| ||Chloramphenicol||+
|-
| ||[[Clindamycin]]||+
|-
| [[Macrolides]]||Erythromycin||+
|-
| ||[[Azithromycin]]||+
|-
| ||Clarithromycin||+
|-
| Ketolide||Telithromycin||+/-
|-
| Tetracyclines||[[Doxycycline]]||+
|-
| ||Minocycline||+
|-
| Glycylcycline||Tigecycline||+
|-
| Glyco/Lipoclycopeptides||[[Vancomycin]]||+
|-
| ||Teicoplanin||+
|-
| ||Telavancin||+
|-
| ||Fusidic Acid||+/-
|-
| ||Trimethoprim||+/-
|-
| ||[[TMP-SMX]]||+
|-
| Urinary Agents||[[Nitrofurantoin]]||+
|-
| ||Fosfomycin||
|-
| Other||[[Rifampin]]||+
|-
| ||[[Metronidazole]]||0
|-
| ||Quinupristin dalfoppristin||+
|-
| ||Linezolid||+
|-
| ||[[Daptomycin]]||+
|-
| ||Colistimethate||0
|}


===Key===
===Key===

Revision as of 07:37, 4 March 2014

Background

Antibiotic Sensitivities[1]

Organisms ' Strep. pneumoniae
Penicillins Penicillin G +
Penicillin V +
Anti-Staphylocccal Penicillins Methicillin +
Nafcillin/Oxacillin +
Cloxacillin/Diclox. +
Amino-Penicillins AMP/Amox +
Amox/Clav +
AMP-Sulb +
Anti-Pseudomonal Penicillins Ticarcillin +
Ticar-Clav +
Pip-Taxo +
Carbapenems Piperacillin +
Doripenem +
Ertapenem +
Imipenem +
Meropenem +
Aztreonam 0
Fluroquinolones Ciprofloxacin +/-
Ofloxacin +/-
Pefloxacin 0
Levofloxacin +
Moxifloxacin +
Gemifloxacin +
Gatifloxacin +
1st G Cephalosporin Cefazolin +
2nd G. Cephalosporin Cefotetan +
Cefoxitin +
Cefuroxime +
3rd/4th G. Cephalosporin CefoTAXime +
Cefizoxime +
CefTRIAXone +
Ceftobiprole +
Ceftaroline +
CefTAZidime +
Cefepime +
Oral 1st G. Cephalosporin Cefadroxil +
Cephalexin +
Oral 2nd G. Cephalosporin Cefaclor/Loracarbef +
Cefproxil +
Cefuroxime axetil +
Oral 3rd G. Cephalosporin Cefixime +
Ceftibuten +/-
Cefpodox/Cefdinir/Cefditoren +
Aminoglycosides Gentamicin 0
Tobramycin 0
Amikacin 0
Chloramphenicol +
Clindamycin +
Macrolides Erythromycin +
Azithromycin +
Clarithromycin +
Ketolide Telithromycin +/-
Tetracyclines Doxycycline +
Minocycline +
Glycylcycline Tigecycline +
Glyco/Lipoclycopeptides Vancomycin +
Teicoplanin +
Telavancin +
Fusidic Acid +/-
Trimethoprim +/-
TMP-SMX +
Urinary Agents Nitrofurantoin +
Fosfomycin
Other Rifampin +
Metronidazole 0
Quinupristin dalfoppristin +
Linezolid +
Daptomycin +
Colistimethate 0

Key

  • S susceptible/sensitive (usually)
  • I intermediate (variably susceptible/resistant)
  • R resistant (or not effective clinically)
  • S+ synergistic with cell wall antibiotics
  • U sensitive for UTI only (non systemic infection)
  • X1 no data
  • X2 active in vitro, but not used clinically
  • X3 active in vitro, but not clinically effective for Group A strep pharyngitis or infections due to E. faecalis
  • X4 active in vitro, but not clinically effective for strep pneumonia

Table Overview

Gram Positives
Cocci
Clusters
Pairs/Chains
Other
Rods
Gram Negatives
Cocci
Rods
Lactose Fermenters
Lactose Non-Fermenters
Other
Rods/Cocci
Anaerobes

See Also

References

  1. ↑ Sanford Guide to Antimicrobial Therapy 2010
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