Cephalexin: Difference between revisions
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==Contraindications== | ==Contraindications== | ||
*Allergy to class/drug | |||
**See also [[Cephalosporin Cross-reactivity]] | |||
*Caution advised with contraceptives | |||
==Adverse Drug Reactions== | |||
==Pharmacology== | ==Pharmacology== | ||
Revision as of 07:48, 5 February 2014
General
- Type: 1st generation cephalosporin
- Dosage forms
- Tabs: 250mg, 500mg, 750mg
- Liquid: 125mg/5mL; 250mg/5mL
- Common Trade Names: Keflex
Adult Dosing
General
250-500mg PO q6h
Strep Pharyngitis
500mg PO q12h x 10 days
Uncomplicated UTI
500mg PO q12h x 7-14 days
Cellulitis and Other Skin Infections
500mg PO q12h
Pediatric Dosing
General
- 25-50 mg/kg/day PO divided q6-12h
Otitis Media
- 75-100 mg/kg/day PO divided q12h x 10 days
- Max: 4,000 mg/24h
Community Acquired Pneumonia
- 75-100 mg/kg/day PO divided q12h x 10 days
Contraindications
- Allergy to class/drug
- See also Cephalosporin Cross-reactivity
- Caution advised with contraceptives
Adverse Drug Reactions
Pharmacology
- Half-life: 1h (~20hr ESRD)
- Metabolism: Minimal
- Excretion: Primarily urine (>90% unchanged)
- Mechanism of Action:
- Bactericidal, inhibits cell wall
Pregnancy/Lactation
- Pregnancy: B
- Lactation: Safe
See Also
Source
- Sanford 2010
- Epocrates