Bumetanide: Difference between revisions
ClaireLewis (talk | contribs) |
(edited dosage forms, strengths, trade names) |
||
| Line 4: | Line 4: | ||
==Administration== | ==Administration== | ||
*Type: Loop [[diuretic]] | *Type: Loop [[diuretic]] | ||
*Dosage Forms: | *Dosage Forms: injectable solution, tablet | ||
*Dosage Strengths: injectable solution: 0.25mg/mL; tablet: 0.5, 1, 2mg | |||
*Routes of Administration: IV, PO | *Routes of Administration: IV, PO | ||
*Common Trade Names: Bumex | *Common Trade Names: Bumex, Burinex | ||
==Adult Dosing== | ==Adult Dosing== | ||
Revision as of 23:13, 11 October 2017
General
- 80-100% oral bioavailability as opposed to furosemide[1]
Administration
- Type: Loop diuretic
- Dosage Forms: injectable solution, tablet
- Dosage Strengths: injectable solution: 0.25mg/mL; tablet: 0.5, 1, 2mg
- Routes of Administration: IV, PO
- Common Trade Names: Bumex, Burinex
Adult Dosing
40mg furosemide = 20mg torsemide = 1mg bumetanide = 50 mg ethacrynic acid
- 0.5 to 1 mg IV or 0.5-2mg PO. If inadequate response, repeat q2-3 hours to maximum of 10 mg per day
Pediatric Dosing
Safety/efficacy not established
Special Populations
- Pregnancy Rating: C
- Lactation risk: Infant risk cannot be ruled out
- Renal dosing: no adjustment
- Hepatic dosing: use lowest dose necessary, titrate slowly
Contraindications
- Allergy to class/drug
- Anuria
- Hepatic coma
- Severe electrolyte depletion
Adverse Reactions
Serious
- SJS
- Encephalopathy
- Thrombocytopenia
Common
- Hypotenchion
- Hypouricemia, hypokalemia, hypochloremia
- Cramps
- Dizziness, headache
- Nausea
Pharmacology
- Rapid onset
- Half-life: 1-6 hours
- Metabolism:
- Excretion: Mostly renal
Mechanism of Action
- Inhibits the reabsorption of sodium and chloride in the ascending limb of the loop of Henle
Comments
See Also
References
- ↑ Asare K. Management of Loop Diuretic Resistance in the Intensive Care Unit. Am J Health Syst Pharm. 2009;66(18):1635-1640.