Blood products: Difference between revisions
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==PRBCs== | ==PRBCs== | ||
===Usual Dose=== | |||
1 U of PRBCs (250 mL or 3 mL/kg in peds) --> incr Hgb ~1.0 | |||
===Indications (by Hb)=== | |||
#Normal (rarely if >10; almost always if <6) | #Normal (rarely if >10; almost always if <6) | ||
#Critically ill, otherwise healthy (keep > 7-9) | #Critically ill, otherwise healthy (keep > 7-9) | ||
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==FFP== | ==FFP== | ||
===Usual Dose=== | |||
#10-20 ml/kg (average adult = 3-6 units) | |||
#2 U of FFP (450 mL) should correct most early coagulopathies | #2 U of FFP (450 mL) should correct most early coagulopathies | ||
#An INR of 2.0 correlates w/ PT 1.5 times nl | #An INR of 2.0 correlates w/ PT 1.5 times nl | ||
Indications | ===Indications=== | ||
# Active bleeding AND PT/PTT >1.5 times nl (INR >2.0) | # Active bleeding AND PT/PTT >1.5 times nl (INR >2.0) | ||
# INR >20.0 | # INR >20.0 | ||
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==Platelets== | ==Platelets== | ||
===Usual Dose=== | |||
#1 U per 10kg (~6-10 U) --> incr plat ~25,000. | |||
#1 U (25-50 mL = "6-pack") --> incr plat 5-10,000 (adult) or 20,000 (20 kg child) | #1 U (25-50 mL = "6-pack") --> incr plat 5-10,000 (adult) or 20,000 (20 kg child) | ||
===Indications=== | |||
See "HEME: Thrombocytopenia | |||
==Risks== | ==Risks== | ||
Revision as of 13:30, 15 March 2011
PRBCs
Usual Dose
1 U of PRBCs (250 mL or 3 mL/kg in peds) --> incr Hgb ~1.0
Indications (by Hb)
- Normal (rarely if >10; almost always if <6)
- Critically ill, otherwise healthy (keep > 7-9)
- Ischemic heart dz/critically ill age >65 (keep >10)
FFP
Usual Dose
- 10-20 ml/kg (average adult = 3-6 units)
- 2 U of FFP (450 mL) should correct most early coagulopathies
- An INR of 2.0 correlates w/ PT 1.5 times nl
Indications
- Active bleeding AND PT/PTT >1.5 times nl (INR >2.0)
- INR >20.0
- Massive PRBC transfusion (>9 U)
- DIC not corrected by cryo.
- Coumadin overdose AND life threat bleed/invasive procedure
Platelets
Usual Dose
- 1 U per 10kg (~6-10 U) --> incr plat ~25,000.
- 1 U (25-50 mL = "6-pack") --> incr plat 5-10,000 (adult) or 20,000 (20 kg child)
Indications
See "HEME: Thrombocytopenia
Risks
- Hep B ~1:100,000
- Hep C ~1:1 million
- HIV 1:2 million
Source
2/18/06 DONALDSON (addapted from Rosen, Lampe, Charfen)