Norepinephrine: Difference between revisions
(Text replacement - "levophed" to "norepinephrine") |
Neil.m.young (talk | contribs) (Text replacement - "β1" to "β<sub>1</sub>") |
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*Mechanism of Action: | *Mechanism of Action: | ||
===Primary Receptor=== | ===Primary Receptor=== | ||
*α1 >> | *α1 >> β<sub>1</sub> | ||
===Relative Effects=== | ===Relative Effects=== | ||
*↑↑↑SVR | *↑↑↑SVR | ||
Revision as of 19:55, 1 August 2017
General
- Type: Vasopressors
- Dosage Forms:
- Common Trade Names: Levophed
Adult Dosing
Dosing
- Usual Adult Dose for Hypotension. Initial dose: 2 to 4 mcg/min with titration to 25 mcg/min
Based on Glomerular Filtration Rate [GFR (ml/min)]
- <10: 0.2mcg/kg/min
- 10-40: 0.3mcg/kg/min
- >40-50: 0.4mcg/kg/min
- For CVVHD: dose at 0.4mcg/kg/min
- For HD: dose 0.2mcg/kg/min
Rate of Titration
- Q2-5 min
Pediatric Dosing
Special Populations
- Pregnancy Rating:
- Lactation:
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
Adverse Reactions
- If extravasation occurs use phentolamine 0.1 to 0.2mg/kg (maximum dose 10mg) subcutaneous in affected site[1][2]
- Consult plastic/general surgery service to follow the patient and eval for need for intervention
Serious
Common
Pharmacology
- Half-life:
- Metabolism:
- Excretion:
- Mechanism of Action:
Primary Receptor
- α1 >> β1
Relative Effects
- ↑↑↑SVR
- ↑HR
- ↑SV
Notes
More potent vasoconstrictor than dopamine and phenylephrine.
Indication
- Septic shock (1st line)
- Cardiogenic shock:
- If marked hypotension (SBP <70)
- If used with dobutamine